目的：探讨糖尿病视网膜病变(DR)患者血清CMKLR1水平及临床意义。

方法：选取2015-02/2018-03在我院治疗的2型糖尿病(T2DM)患者140例，其中单纯T2DM患者45例，DR患者95例(NPDR患者54例，PDR患者41例)，并纳入健康志愿者40例。收集临床资料并检测血清CMKLR1水平。

结果：PDR患者糖尿病病程长于NPDR和NDR患者，且NPDR患者长于NDR患者(均P<0.05)。T2DM患者FPG和血清TG水平升高，HDL-C水平降低，且DR患者LDL-C水平高于NDR患者和健康志愿者(均P<0.05)。PDR患者血清CMKLR1水平高于NPDR、T2DM患者和健康志愿者，且NPDR患者高于NDR患者和健康志愿者，NDR患者高于健康志愿者(均P<0.05)。DR患者血清CMKLR1水平与糖尿病病程、HbA1c和LDL-C呈正相关(r=0.374、0.248、0.304，均P<0.05)，其中糖尿病病程和血清CMKLR1水平是DR发生的危险因素(OR=1.594、1.830，均P<0.05)。

结论：DR患者血清中CMKLR1水平升高，且与病情进展有关，是影响DR发生发展的重要危险因素。

METHODS: A total of 140 patients with type 2 diabetes(T2DM)treated in our hospital were selected from February 2015 to March 2018, including 45 patients with type 2 diabetes(T2DM group)and 95 patients with DR(54 patients with NPDR and 41 patients with PDR). And 40 healthy volunteers were collected. Clinical data was collected and serum levels of CMKLR1 were detected.

RESULTS: The duration of diabetes in patients with PDR was longer than that in the patients with NPDR and NDR, and the patients with NPDR was longer than the patients with NDR(all P<0.05). The FPG and serum level of TG in the patients with T2DM were elevated, and the level of LDL-C in the patients with DR was higher than that in the patients with NDR and the healthy volunteers(all P<0.05). The serum level of CMKLR1 in the patients with PDR was higher than that in the patients with NPDR, T2DM and the healthy volunteers, and the patients with NPDR was higher than the patients with NDR and the healthy volunteers, the patients with NDR was higher than the healthy volunteers(all P<0.05). The serum level of CMKLR1 in patients with DR was positively correlated with the duration of diabetes, HbA1c and LDL-C(r=0.374, 0.248 and 0.304; all P<0.05). The duration of diabetes and the serum level of CMKLR1 were risk factors for DR(OR=1.594 and 1.830, all P<0.05).

CONCLUSION: The serum level of CMKLR1 in patients with DR was increase, and related to the progression of the disease. It was an important risk factor affecting the occurrence and progression of DR.