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[摘要]
目的：研究血清中血小板源性生长因子-BB(PDGF-BB)的水平与2型糖尿病患者DR的相关性。
方法：以健康体检者为对照组(75例)，糖尿病病例组分为NDR 25例、NPDR 25例和PDR 25例。用ELISA测定各组样本血清中PDGF-BB水平，并分析血清PDGF-BB与糖尿病病程、HbA1c等各项生化指标的关系，分析PDGF-BB与黄斑厚度的关系。
结果：对照组、NDR组、NPDR组、PDR组血清PDGF-BB水平各组间均有差异(F=14.259，P<0.01)。NPDR组、PDR组血清PDGF-BB水平(535.67±69.21、551.60±103.46pg/mL)均高于对照组、NDR组(400.28±44.55、409.65±50.37pg/mL)。多元回归分析血清PDGF-BB水平与空腹血糖(FPG)、甘油三酯(TG)、糖尿病病程有相关性(均P<0.05)。PDR组血清PDGF-BB水平与黄斑厚度存在相关性(r=0.613，P<0.05)，对照组、NDR组、NPDR组血清PDGF-BB水平与黄斑厚度无相关性(r=0.013、0.051、0.062，均P>0.05)。
结论：血清PDGF-BB水平随着DR病变程度加重而升高，与黄斑水肿存在相关性，并与FPG、TG、糖尿病病程有相关性，可以考虑作为DR的生物学标志物。
[Key word]
[Abstract]
AIM:To observe the correlation between serum level of platelet derived growth factor -BB(PDGF-BB)and diabetic retinopathy(DR)in type 2 diabetic patients.
METHODS: Seventy-five cases of healthy subjects underwent physical examination were taken as control group. Diabetic patients were divided into non-diabetic retinopathy group(NDR, 25 cases), non-proliferative diabetic retinopathy group(NPDR, 25 cases)and proliferative diabetic retinopathy group(PDR, 25 cases). Serum level of each group was measured using Enzyme-Linked Immunosorbent Assay(ELISA). Correlation between serum PDGF-BB level and stages of diabetes mellitus, macular thickness, glycosylated hemoglobin, and other biochemical indexes in serum were analyzed.
RESULTS: Serum level of PDGF-BB in control group(400.28±44.55pg/mL), NDR(409.65±50.37pg/mL), NPDR(535.67±69.21pg/mL)and PDR subgroup(551.60±103.46pg/mL)were significantly different(F=14.259, P<0.01). Serum level of PDGF-BB in NPDR group and PDR group were higher compared to control group and NDR subgroup. Multiple regression analysis showed that serum level of PDGF-BB positively correlated with fasting blood glucose(FBG), triglycerides(TG)and stages of diabetes(P<0.05). Serum level of PDGF-BB in PDR subgroup correlated with the thickness of macular(r=0.613, P<0.05). Whereas, this correlation was not observed in other groups(rC=0.013, rNDR=0.051, rNPDR=0.062; P>0.05).
CONCLUSION: Serum PDGF-BB level was observed to rise with severity of DR and relevant to macula edema. It was also positively correlated to FPG, TG and stages of diabetes. PDGF-BB could be recommended as diagnostic biomarker for DR.
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