目的：探讨PDR患者给予雷珠单抗辅助25G玻璃体切割术治疗后的临床疗效。

方法：选取2014-10/2017-11于我院就诊的PDR患者120例120眼作为研究对象。常规组患者60例60眼给予单纯25G玻璃体切割术治疗，研究组患者60例60眼给予雷珠单抗辅助25G玻璃体切割术治疗。术后随访6mo，对比两组患者手术时长、术中与术后情况、术后并发症，以及术前、术后6mo时BCVA、眼压、黄斑中心区厚度变化。

结果：研究组手术平均时长显著低于常规组(t=5.727，P<0.05)； 研究组术后高眼压、出血明显且需电凝、医源性视网膜裂孔、虹膜新生血管发生率均低于常规组(P<0.05)； 研究组术后并发症总发生率(5.0%)低于常规组(16.7%)，两组间有统计学差异(χ²=4.227，P<0.05)。研究组术后6mo眼压和黄斑中心区厚度低于常规组，BCVA优于常规组(t=3.362、2.486、8.028，均P<0.05)。

结论：PDR患者给予雷珠单抗辅助25G玻璃体切割术治疗可有效缩短手术时间，改善黄斑水肿情况，减少术后出血和并发症发生率。

METHODS: Totally 120 patients(120 eyes)from our hospital from October 2014 to November 2017 were selected as subjects, and randomly divided into 2 groups. Sixty patients(60 eyes)in the conventional group were treated with 25G vitrectomy alone. Sixty patients(60 eyes)in the study group were treated with ranibizumab adjuvant 25G vitrectomy. The patients were followed up for 6mo. The duration of operation, intraoperative and postoperative conditions, postoperative complications, and the BCVA, intraocular pressure, central area of the macula in preoperative and postoperative 6mo were compared.

RESULTS: The average duration of surgery in the study group was significantly lower than that in the conventional group(t=5.727, P<0.05). The incidence of postoperative high intraocular pressure, electrocoagulation hemostasis, iatrogenic retinal tears, and INV(iris neovascularization)were significantly lower in the study group than in the conventional group(P<0.05), the overall incidence was significantly lower than the conventional group(5.0% vs 16.7%, χ²=4.227, P<0.05). The intraocular pressure and the thickness of the central area of the macula of the study group was significantly lower than that of the conventional group at 6mo after operation, the BCVA was significantly better than the conventional group(t=3.362, 2.486, 8.028, all P<0.05).

CONCLUSION: PDR patients treated with ranibizumab-assisted 25G vitrectomy can effectively shorten the operation time, improve macular edema, reduce the incidence of postoperative bleeding and complications, and be safe and reliable.