目的：探讨玻璃体腔注射康柏西普对湿性年龄相关性黄斑变性(ARMD)的疗效及对脉络膜厚度的影响。

方法：回顾性研究。选取本院于2014-03/2017-12收治的213例345眼湿性ARMD患者，根据治疗方式不同分为两组，对照组(106眼176眼)行玻璃体腔注射曲安奈德治疗，观察组(107例169眼)行玻璃体腔注射康柏西普治疗。分析两组患者的疗效及脉络膜厚度变化。

结果：两组患者注射前BCVA、黄斑中央区厚度(CMT)均无差异(P>0.05)。观察组第3次注射后的BCVA优于对照组，且CMT值低于对照组(P<0.05)。两组患者间治疗前和治疗后1、3、6mo的中央视网膜厚度、脉络膜厚度无差异(P>0.05)。但两组患者治疗后6mo的中央视网膜厚度、脉络膜厚度显著低于治疗前和治疗后1、3mo(P<0.05)。经治疗后，观察组与对照组的并发症总发生率分别为5.7%、7.7%(P>0.05)。

结论：玻璃体腔注射康柏西普与注射曲安奈德的效果同样好，不仅可以改善和稳定患者视力，还能有效降低患者的中央视网膜厚度和脉络膜厚度，其疗效显著，安全性较高。

METHODS: A total of 213 patients(345 eyes)with ophthalmologic diseases who were treated in our hospital from March 2014 to December 2017 were randomly divided into control group(n=106, 176 eyes)and observation group(n=107, 169 eyes). The control group was treated with intravitreal injection of triamcinolone acetonide and the observation group was treated with intravitreal injection of conbercept. The efficacy of the two groups and changes in choroidal thickness were compared and analyzed.

RESULTS: There was no significant difference in BCVA and CMT between the two groups before and after injection(P>0.05). However, BCVA and CMT in observation group and control group were significantly better than those before injection(P<0.05), and there was significant difference between before and after injection. There was no significant difference in central retinal thickness and choroid thickness between the two groups at baseline(1, 3, 6mo)(P>0.05). However, the central retinal thickness and choroid thickness at 6mo were significantly lower than those at baseline and 1, 3mo(P<0.05), which were statistically significant. After treatment, the total incidence of complications in the observation group and the control group were 5.7% and 7.7%, respectively, with no significant difference between the two groups(P>0.05).

CONCLUSION: Intravitreal injection of conbercept and triamcinolone acetonide has the same effect, which can not only improve and stabilize the visual acuity of patients, but also reduce the central retinal thickness and choroid thickness effectively. It has obvious curative effect and high safety, and has clinical application value.