目的：评价小梁切除联合使用5-氟尿嘧啶术后行激光断线后的眼压变化，及其与激光断线时机的相关性。

方法：选取我院行小梁切除联合使用5-氟尿嘧啶的原发性慢性闭角型青光眼患者60例60眼，根据其术后眼压情况(21mmHg为激光断线的目标眼压)行激光断线。根据术后至激光断线的时间，将患者分为三组：<2wk组、2～4wk组、>4wk组。随访观察激光断线前后的眼压情况。

结果：三组患者激光断线前眼压无差异(P=0.999)，激光断线即刻和激光断线后12wk，三组间眼压有差异(P<0.05)。激光断线2～4wk组中，74%患者可达到目标眼压。目标眼压达标率与激光断线时间点呈负相关(P_trend=0.069)。

结论：小梁切除联合使用5-氟尿嘧啶术后2～4wk行激光断线是一种降低眼压安全、有效的方法。

METHODS: Prospective interventional study of sixty eyes of sixty patients. Trabeculectomy associated with 5-Fluoroaracil was performed for 60 patients with glaucoma. Laser suture lysis was carried out according to the IOP of post trabeculectomy. 21mmHg was used as the cut off for the achievement of target IOP. According to the timing of laser suture lysis, patients post trabeculectomy were divided into three groups: <2wk, 2^nd-4^thwk and >4wk.

RESULTS: The differences of IOP prelaser suture lysis showed no statistical significance among three groups(P=0.999). The difference of IOP following 12wk post laser suture lysis showed significant statistical significance(P<0.05)among three groups. When laser suture lysis was performed during 2^nd-4^th week post trabeculectomy, 28 patients(74%)achieved the target IOP. Target IOP achieved is negatively correlated to higher week of lysis(P_trend=0.069).

CONCLUSION: Laser suture lysis during 2^nd-4^th week post trabeculectomy associated with 5-Fluoroaracil is an effective and safe technique for reducing IOP.