目的：评估不同程度远视屈光参差性弱视的波前像差特点。

方法：远视屈光参差性弱视60例被纳入本研究，并被分成轻、中、重度三组，各组按矫正视力再分为弱视眼与对侧眼亚组。所有患者双眼均接受散瞳后波前像差检测。分析组内和组间双眼间波前像差差异。

结果：轻、中、重度弱视各组内弱视眼与对侧眼的等效离焦度、矫正视力均有差异(P<0.01)。轻度弱视患者中，弱视眼仅四阶像差RMS值高于对侧眼(P<0.01)； 中、重度弱视组内弱视眼仅总像差RMS值高于对侧眼(均P<0.01)。三组间仅双眼间三阶像差RMS差值有差异(P<0.01)，中度与轻度、重度组间均有差异(P<0.05)。

结论：散瞳状态下，双眼间波前像差在轻度弱视表现为弱视眼四阶像差RMS值高于对侧眼，在中、重度弱视表现为弱视眼的总像差RMS值高于对侧眼； 双眼间波前像差RMS差值在屈光参差性弱视表现为中度弱视的三阶像差RMS差值低于轻度、重度弱视。

METHODS: Sixty hyperopic anisometropic amblyopia were enrolled and divided into mild, moderate and severe groups. Each group was then divided into amblyopic eye(AE)and fellow eye(FE)subgroups according to the corrected visual acuity of each subject. All patients underwent wavefront analysis with iDesign^© wavefront aberration system(AMO, USA)in mydriasis condition. Paired t-test was used to compare interocular differences of aberration parameters within groups.

RESULTS: Paired t-test showed that significant differences in defocus equivalent(DE), BCVA between AE and FE in mild, moderate and severe anisometropic amblyopia(all P<0.01). No significant interocular difference was noticed in mild group except for forth-order aberration RMS(P<0.01). And No significant interocular differences were noticed in moderate and severe group except for total aberration RMS(both P<0.01). One-way ANOVA showed that significant interocular differences were noticed in third-order aberration RMS among the groups(P<0.01). LSD showed that interocular difference of third-order aberration RMS in moderate group was significant lower than that in mild and moderate groups(both P<0.05).

CONCLUSION: In mydriasis condition, mild anisometropic amblyopia showed higher forth-order aberration RMS in AE than that in FE, moderate and sever amblyopia showed higher total aberration RMS in AE than that in FE. Moderate anisometropic amblyopia manifested lower interocular differences of third-order aberrations RMS than mild and severe amblyopia, but no significant interocular differences observed between mild and severe amblyopia.