目的：观察2型糖尿病患者肾小球滤过率(eGFR)与糖尿病性黄斑水肿(DME)之间的关系。

方法：选取2015-05/2017-05抚顺市眼病医院糖尿病眼病专科门诊在社区筛查的2型糖尿病患者912例，进行眼底照相、空腹血糖、糖化血红蛋白、肾功能等检查，应用我国eGFR课题协作组改良的简化MDRD方程估算eGFR。

结果：选取的912例2型糖尿病患者中无DME、轻度DME、中度DME、重度DME患者分别为815例、29例、21例、47例，随着DME病情的加重，患者eGFR逐渐降低(F=8.87，P<0.001)。Logistic回归分析显示，eGFR降低是DME发生的危险因素，且eGFR每下降20.3mL/(min·1.73m²)(1个标准差)，发生DME的风险增加1.84倍，肾功能受损及肾功能不全者发生DME的风险是肾功能正常者的1.60及2.46倍。

结论：eGFR为DME发生的危险因素，与DME严重程度相关，临床治疗中应关注DME患者肾功能情况。

METHODS: A total of 912 T2DM patients were enrolled in this study and underwent fundus colorized photography, fasting blood-glucose, glycated hemoglobin and renal function examinations. Estimated glomerular filtration rate assessed using modified abbreviated MDRD equation by Chinese eGFR investigation collaboration.

RESULTS:Among them, 29, 21 and 47 patients had mild, moderate and severe DME, 815 patients not had DME, respectively. GFR was gradually decreased in patients with no DME, mild DME,moderate DME and severe DME(F=8.87, P<0.001). Logistic regression analysis demonstrated that lower levels of GFR was significantly associated with presence of DME. And for every 20.3 \〖mL·min^-1·(1.73m²)^-1\〗 decrease in eGFR, the risk of DME increased by 1.84 times. Impaired renal function and kidney disease were associated with the presence of DME when compared to normal renal function in multivariable models(1.60 and 2.46 times).

CONCLUSION: In T2DM patients, lower eGFR is an independent risk factors for DME, and physicians were reminded to pay attention to changes in renal function when monitoring DME.