维生素A棕榈酸酯联合妥布霉素修复角膜上皮损伤

Clinical observation of vitamin A Palmitate Eye Gel combined with Tobramycin Eye Drops in repairing of corneal epithelial defect

摘要:

目的：探讨维生素A棕榈酸酯眼用凝胶联合妥布霉素眼液对角膜上皮损伤疾病的临床疗效。

方法：选取2015-05/2016-03来我院就诊的角膜上皮缺损患者80例100眼作为研究对象，随机分为治疗组和对照组。治疗组采用维生素A棕榈酸酯眼用凝胶联合妥布霉素眼液治疗，对照组患眼仅应用妥布霉素眼液治疗。比较两组治疗2、4wk后的疗效。

结果：治疗组痊愈率为80%，有效率为94%。对照组痊愈率为70%，有效率为78%，两组患者之间有效率差异有统计学(P<0.05)。SⅠt以及BUT结果显示与对照组比较，治疗组的时间显著延长(P<0.01)。治疗组的患者治疗2wk后的症状体征评分明显低于对照组(P<0.01)，但治疗4wk后，两组的症状体征评分差异无统计学意义(P>0.05)。

结论：维生素A棕榈酸酯眼用凝胶联合妥布霉素眼液能够明显改善眼干症状，且能够有效缩短角膜上皮的愈合时间，是一种治疗角膜上皮损伤的有效方法。

Abstract:

AIM: To investigate the clinical effect of vitamin A Palmitate Eye Gel combined with Tobramycin Eye Drops on corneal epithelial injury.

METHODS: Totally 80 patients(100 eyes)with corneal epithelial injury who came to our hospital from May 2015 to March 2016 were randomly divided into treatment group(50 eyes)and control group(50 eyes). The treatment group was treated with vitamin A Palmitate Eye Gel combined with Tobramycin Eye Drops, while the control group was treated with Tobramycin Eye Drops only. The curative effect of two groups was compared after 2wk and 4wk of treatment.

RESULTS: The cure rate was 80% and the effective rate was 94% in the treatment group. The cure rate was 70% and the effective rate was 78% in the control group. There was significant difference in the effective rate between the two groups(P<0.05). The results of SⅠt and BUT test showed that the time of treatment group was significantly longer than that of control group(P<0.01). The score of symptoms and signs in the treatment group was significantly lower than that in the control group after 2wk of treatment(P<0.01), but there was no significant between treatment groups and control grouop after 4wk of treatment(P>0.05).

CONCLUSION: Vitamin A Palmitate Eye Gel combined with Tobramycin Eye Drops can significantly improve dry eye symptoms and effectively shorten the healing time of corneal epithelium. It is an effective method to treat corneal epithelial injury.