[关键词]
[摘要]
目的:探讨苏州某社区高血压患者视网膜动脉狭窄的危险因素及与尿白蛋白/肌酐的(UACR)关系,为靶器官损害的预防、延缓提供一定依据。
方法:本研究采用横断面调查的方法,纳入高血压患者1 983例,根据眼底检测情况分成正常组944例,狭窄组1 039例。收集基线资料及进行尿白蛋白/尿肌酐测定,分析视网膜动脉狭窄危险因素及与UACR的关系。
结果:两组患者年龄、糖尿病水平比较,差异均有统计学意义(P<0.05); 年龄(OR=1.013,P=0.011)、糖尿病(OR=1.352,P=0.008)为视网膜动脉狭窄的危险因素; 高血压视网膜病变(HR)检出率为95.56%,其中以Ⅰ级和Ⅱ级轻度病变为主; 两组患者白蛋白尿分组差异有统计学意义(P<0.05),其中眼底狭窄组大量白蛋白尿占比65.59%,高于微量白蛋白尿54.21%,高于正常组50.52%。
结论:年龄和糖尿病是高血压患者视网膜动脉狭窄的危险因素,视网膜病变与UACR有关系,社区应加强健康宣教,早期进行视网膜、肾脏筛查,预防、延缓病情进展。
[Key word]
[Abstract]
AIM: To explore the risk factors of retinal artery stenosis and its relationship with urinary albumin/creatinine in patients with hypertension, so as to provide a basis for prevention of target organ damage.
METHODS: In this study, a cross-sectional study was conducted in 1 983 patients with hypertension. According to the fundus examination, 944 patients were divided into normal group and 1 039 patients were divided into abnormal group. Baseline data were collected and urine albumin/creatinine was measured. Analysis of risk factors for retinal artery stenosis and its relationship with urinary albumin/creatinine.
RESULTS: There were significant differences in age and diabetes between the two groups(P<0.05). Logistic regression showed that age(OR=1.013, P=0.011)and diabetes mellitus(OR=1.352, P=0.008)were risk factors for retinal artery stenosis. Hypertensive retinopathy(HR)detection rate was 95.56%. Grade I and grade II mild lesions were the major ones. The proportion of macroalbuminuria in retinal stenosis group was 65.59%, higher than that in microalbuminuria group(54.21%)and normal group(50.52%).
CONCLUSION: Age and diabetes are risk factors for retinal artery stenosis in hypertensive patients. Retinopathy is associated with urinary albumin/creatinine. The community should strengthen health education and early screening of retina and kidney to prevent the progress of the disease.
[中图分类号]
[基金项目]
苏州高新区人民医院科学创新基金项目(No.SGY2018B06)