糖尿病性白内障患者糖代谢异常、胰岛素抵抗与房水及血清中炎症因子的相关性分析

Correlation of abnormal glucose metabolism, insulin resistance and inflammatory factors in aqueous humor and serum in diabetic cataract patients

摘要:

目的：通过测定糖尿病性白内障患者血清中糖代谢指标、胰岛素抵抗与房水和血清中炎症因子的水平，探讨其相关性。

方法：随机选取我院2017-02/2018-01糖尿病性白内障患者69例(观察组)和白内障患者65例(对照组)，检测两组患者血清中糖化血红蛋白(HbA1c)、空腹血糖(FPG)、空腹胰岛素(FINS)的水平，计算胰岛素抵抗指数(HOMA-IR)； 同时检测房水和血清中的胰岛素样生长因子-1(IGF-1)、白细胞介素-6(IL-6)含量，对HbA1c、HOMA-IR与房水和血清中IGF-1、IL-6含量进行相关性分析。

结果：对照组血清中的FPG、HbA1c、HOMA-IR，以及房水和血清中IGF-1、IL-6含量显著低于观察组，差异有统计学意义(均P<0.05)。HbA1c与房水及血清中的IGF-1和IL-6均呈正相关(P<0.05)。HOMA-IR与房水及血清中的IGF-1和IL-6均呈正相关(P<0.05)。

结论：糖尿病性白内障患者HbA1c、HOMA-IR与房水及血清中的IGF-1、IL-6含量具有相关性，通过对上述指标的测定可以辅助判断病情。

Abstract:

AIM:To explore the correlation between glucose metabolism, insulin resistance and inflammatory factors in aqueous humor and serum in patients with diabetic cataract.

METHODS:Sixty-nine patients with diabetic cataract and sixty-five patients with simple cataract were randomly selected from February 2017 to January 2018 in our hospital. The fasting blood glucose(FPG),glycosylated hemoglobin(HbA1c),insulin resistance index(HOMA-IR)in serum, and IGF-1, IL-6 in aqueous humorand serum were compared between the two groups. HbA1c,HOMA-IR, IGF-1 and IL-6 for correlation were analyzed respectively.

RESULTS: The levels of FPG,HbA1c, HOMA-IR in serum, and IGF-1, IL-6 in aqueous humor and serum in the control group were significantly lower than those in the observation group(P<0.05). Positive correlation between HbA1c and IGF-1, IL-6 in aqueous humor and serum(P<0.05). Positive correlation between HOMA-IR and IGF-1, IL-6 in aqueous humorand serum(P<0.05).

CONCLUSION: HbA1c and HOMA-IR in diabetic cataract patients are correlated with IGF-1 and IL-6 contents in aqueous humor and serum. The above indicators can be used to determine the condition.