糖尿病病程对合并糖尿病的白内障患者眼表的影响

Effect of diabetes duration on ocular surface of cataract patients with diabetes mellitus

摘要:

目的：观察不同糖尿病病程对白内障患者术前干眼及眼表的影响。

方法：观察我院2018-03/08合并糖尿病的白内障患者眼表及干眼情况。按照糖尿病病程分组，分为<5a，5～15a，>15a三个组。比较三组患者年龄、性别、泪膜破裂时间(break-up time， BUT)，Schirmer I试验，角膜荧光染色(fluorescein cornea staining， FL)，睑缘形态、睑板腺分泌功能以及眼表疾病评分量表(OSDI)。

结果：三组患者年龄、性别差异均无统计学意义。三组间BUT和SchirmerⅠ及OSDI评分差异均无统计学意义，但随着糖尿病病程的延长，OSDI评分逐渐增加。FL和睑板腺分泌在不同病程组比较差异有统计学意义(χ²=8.372、9.346，P=0.015、0.009)，睑缘形态差异无统计学意义(χ²=0.353，P=0.838)。

结论：随着糖尿病病程延长，合并糖尿病的白内障患者眼表及干眼病可能更加严重。对于长期糖尿病患者白内障手术围手术期，需要更加关注眼表的健康及恢复情况。

Abstract:

AIM: To observe the effects of different duration of diabetes on dry eye and ocular surface before cataract surgery.

METHODS: The patients with diabetes and cataract were included from March to August in 2018. According to the duration of diabetes, the patients were divided into three groups(<5a, 5-15a, >15a). Age, sex, break-up time(BUT), Schirmer Ⅰ test, corneal fluorescein cornea staining(FL), palpebral margin staining score, meibomian glands secretion function score, and ocular surface disease score(OSDI)were compared between the three groups.

RESULTS: There were no significant differences in age and sex between the three groups. There were no significant difference in BUT and Schirmer Ⅰ test and OSDI score among the three groups, but the more duration of diabetes was, the more OSDI score was. FL and the secretion of tarsal gland were significantly different between groups(χ²=8.372, 9.346, P=0.015, 0.009, respectively). There was no significant difference in the shape of palpebral margin(χ²= 0.353, P=0.838).

CONCLUSION: The more duration of diabetes is, more serious the ocular surface and dry eye diseases may be. For the patient with long-term diabetic, more attention should be paid to the eye surface health and perioperative recovery.