利用眼反应分析仪评估FS-LASIK和LASEK术后角膜生物力学稳定性
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黑龙江省卫生厅科研课题(No.2016-034)


Comparison on biomechanical stability between femtosecond laser assisted LASIK and LASEK with ocular response analyzer
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Scientific Research Project of Heilongjiang Provincial Health Department(No.2016-034)

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    摘要:

    目的:利用眼反应分析仪(ORA)评估飞秒激光辅助的准分子激光原位角膜磨镶术(FS-LASIK)和准分子激光上皮下角膜磨镶术(LASEK)术后角膜生物力学稳定性的差异。

    方法:选取2016-01/2017-12于我院眼科视光学中心就诊且行LASEK/FS-LASIK手术的近视患者117例200眼(等效球镜-2.00~-5.00D),其中行FS-LASIK术者64例100眼(FS-LASIK组); 行LASEK术者53例100眼(LASEK组)。分别于术前和术后1、3mo采用ORA检测两组患者的角膜滞后量(CH)和角膜阻力因子(CRF)值,并进行统计分析。

    结果:手术前后,两组患者CH和CRF比较,差异均有统计学意义(P<0.05)。术后1、3mo,两组患者CH和CRF均低于术前,差异均有统计学意义(P<0.05)。术后1mo,FS-LASIK组患者CH和CRF均低于LASEK组,差异均有统计学意义(P<0.05)。

    结论:LASEK和FS-LASIK两种术式均会对角膜生物力学稳定性产生一定影响,但LASEK手术比FS-LASIK手术产生的影响更小,更安全,可减少术后屈光回退的可能性。

    Abstract:

    AIM: To compare the difference of biomechanical stability after a femtosecond laser-assisted in situ keratomileusis(FS-LASIK)and laser-assisted subepithelial keratomileusis(LASEK)by ocular response analyzer(ORA).

    METHODS: This prospective study was conducted at the First Affiliated Hospital of Harbin Medical University, and myopic patients with the equivalent sphere between -2.00 and -5.00 diopters from January 2016 and December 2017 were enrolled. All the subjects were divided into FS-LASIK and LASEK group respectively according to different surgical methods. There were 64 patients(100 eyes)participated in the FS-LASIK group while 53 patients(100 eyes)in the LASEK surgery group. Corneal hysteresis value(CH)and corneal resistance factor value(CRF)were measured pre-, 1mo and 3mo postoperation of all the subjects. And the variance analysis of two groups was repeated to compare the overall difference between the two modes of operation from pre-operation to post operation.

    RESULTS: The CH and CRF value of the two groups were different before and after operation(P<0.05). The comparison results of repeated measurements showed that the CH value and CRF value of the surgical methods were reduced in 1 and 3mo after operation, respectively, and there was significance(P<0.05). The CH and CRF of FS-LASIK group was lower than LASEK group only in 1mo after the operation(P<0.05).

    CONCLUSION: Both surgeries could affect the biomechanical stability of cornea. From the point of view of biomechanical stability, LASEK operation is safer than FS-LASIK operation and reduces the possibility of postoperative refractive regression.

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康杨,胡琦,李雪,等.利用眼反应分析仪评估FS-LASIK和LASEK术后角膜生物力学稳定性.国际眼科杂志, 2018,18(11):2116-2118.

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  • 收稿日期:2018-04-10
  • 最后修改日期:2018-09-26
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  • 在线发布日期: 2018-10-22
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