糖尿病患者视网膜神经纤维层厚度与HbA1c水平的相关性分析

Correlation between the RNFL thickness and HbA1c in patients at early stage of type 2 diabetes

摘要:

目的：探讨早期2型糖尿病患者视网膜神经纤维层(RNFL)厚度及其与糖化血红蛋白(HbA1c)的相关性。

方法：将本院2015-10/2017-01收治的58例2型早期糖尿病患者作为试验组，及同期进行健康体检的正常人18例为对照组。使用OCT对所有研究对象进行RNFL厚度测量，比较糖尿病患者RNFL厚度与HbA1c水平的相关性。

结果：试验组上方、下方及鼻侧RNFL厚度值与对照组比较，差异有统计学意义(P<0.05)，与糖尿病病程及HbA1c水平也有显著相关性(P<0.05)，颞侧RNFL值与对照组比较，差异无统计学意义(P>0.05)，与糖尿病病程及HbA1c水平无显著相关性(P>0.05)。

结论：糖尿病患者RNFL厚度明显变薄，且与糖尿病病程及HbA1c水平有显著相关性，临床可根据HbA1c水平评估患者的RNFL变化，推测DR严重程度，从而指导临床诊疗。

Abstract:

AIM: To investigate the relationship between the glycosylated hemoglobin(HbA1c)and retinal nerve fiber layer(RNFL)thickness in patients at early stage of type 2 diabetes.

METHODS: Totally 58 patients at early stage of type 2 diabetes(average disease course was 3.25±2.32a)and 18 healthy subjects were recruited for this study. Optical coherence tomography(OCT)was used to measure retinal nerve fiber layer(RNFL)thickness of all subjects.

RESULTS: The difference of the superior, inferior and nasal RNFL thickness between two groups was significant(P<0.05), and the superior, inferior and nasal RNFL thickness was negatively related to the HbA1c and disease course(P<0.05). No significant difference of temporal RNFL thickness existed between two groups(P>0.05), and temporal RNFL thickness was not related to HbA1c and disease course(P>0.05).

CONCLUSION: RNFL thickness are thinner in diabetes patients than that in healthy subjects, and HbA1c and RNFL thickness are correlated in diabetes patients. Clinically, RNFL changes of patients can be evaluated according to HbA1c level, and the severity of DR can be predicted, thus guiding the clinical diagnosis and treatment.