多巴丝肼片联合视力遮盖法治疗儿童弱视的临床疗效

Clinical effect of levodopa and benserazide hydrochloride tables combined with visual occlusion for amblyopia in children

摘要:

目的：研究视力遮盖法联合口服多巴丝肼片对弱视儿童患者的治疗效果。

方法：选取2016-01/2017-01在我院确诊患有弱视的儿童90例140眼，随机分成单一治疗组和联合治疗组，并选取35例70眼健康儿童作为正常组进行比较。单一治疗组患者采用视力遮盖法进行治疗，联合治疗组患者在使用视力遮盖法的基础上口服多巴丝肼片进行联合治疗。提取两组患儿治疗前后和正常组的泪液，采用酶联免疫吸附法对140眼弱视患儿及正常组儿童70眼泪液中IL-1β、IL-6和IL-9进行检测，采用免疫透射比浊法检测140眼弱视患儿及正常组儿童70眼泪液中环磷腺苷效应元件结合蛋白(CREB)、PKA的蛋白水平。比较两组患者及正常组的指标水平以及不同年龄组治疗有效率及不同方法治疗总有效率。

结果：治疗后，联合治疗组泪液中IL-1β、IL-6、IL-9和CREB、PKA水平明显低于单一治疗组，差异有统计学意义(P<0.05)； 联合治疗组和单一治疗组患儿3～6岁阶段的治疗总有效率显著高于7～9岁和10～12岁阶段的治疗总有效率，差异有统计学意义(P<0.05)； 联合治疗组治疗总有效率明显高于单一治疗组，差异有统计学意义(P<0.05)。

结论：多巴丝肼片联合视力遮盖法能够对儿童的弱视情况作出及时的改善治疗，治疗时间阶段越早越好，且有效率较高。

Abstract:

AIM:To study the therapeutic effect of visual occlusion combined with levodopa and benserazide hydrochloride tables on children with amblyopia.

METHODS: Totally 90 cases(140 eyes)of children diagnosed with amblyopia in our hospital were selected from January 2016 to January 2017. They were randomly divided into the monotherapy group and the combined treatment group, and 35 healthy children(70 eyes)were selected as the normal group for comparison. Patients in the monotherapy group were treated with visual cover, while patients in the combined treatment group were treated with oral administration of levodopa and benserazide tablets on the basis of visual cover. Tears were extracted from both groups of children before and after treatment, and the protein levels of CREB and PKA in tears of 140 eyes and 70 eyes of children in the normal group were detected by enzyme-linked immunosorbent assay. The index levels of the two groups and the normal group were compared, as well as the therapeutic efficiency of different age groups and the total therapeutic efficiency of different methods.

RESULTS: After treatment, the levels of IL-1β, IL-6 and IL-9 in the combined treatment group were significantly lower than those in the single treatment group after treatment(P<0.05).After treatment, the levels of CREB and PKA in the combined treatment group were significantly lower than those in the single treatment group(P<0.05).The total effective rate of children at the age of 3-6 in the combined treatment group and the single treatment group was significantly higher than those at the age of 7-9 and 10-12 in each group(P<0.05). The total therapeutic efficiency of the combined treatment group was significantly higher than that of the single treatment group, and the difference was statistically significant(P<0.05).

CONCLUSION: Combined with the traditional masking method, levodopa and benserazide hydrochloride tables can improve the treatment of children's amblyopia. The earlier the treatment time, the better and the higher efficiency is.