目的：探讨脱抑制及视功能训练治疗屈光参差性弱视患儿的临床疗效。

方法：前瞻性病例对照研究。83例屈光参差性弱视患儿纳入本研究，所有患儿均为单眼弱视，随机分为训练组(44例44眼)和对照组(39例39眼)。所有患儿常规配镜，定量遮盖，均采用家庭+诊室训练相结合的方法。对照组训练内容为：弱视训练仪(光刷、红闪、光栅等)及电脑软件精细+刺激训练。训练组除完成对照组训练项目以外，当患儿弱视眼矫正视力已经提高到0.6以上后进行单眼调节功能训练、脱抑制训练、双眼调节功能训练及双眼集合、融像功能训练。随访6mo后，对两组的视力疗效及远近立体视功能检查结果进行比较及统计学分析。

结果：训练组与对照组相比，两个组间视力改善的总有效率差异无统计学意义，但是两个组间整体的视力疗效比较差异有统计学意义(P<0.05)，加入脱抑制及视功能训练后训练组远、近立体视功能改善的人数明显优于对照组，差异有统计学意义(P<0.05)。

结论：弱视治疗中加入脱抑制训练及双眼视功能训练后，能够增强弱视眼的竞争力，消除抑制，不但能提高视力，还能建立良好的视功能。

METHODS: Eighty-three children patients with anisometropic amblyopia were enrolled in the prospective case control study. All patients were monocular amblyopia, which were randomly classified into 2 groups as a training group(44 cases)and a control group(39 cases). All patients had routine glasses and quantitative coverage, and were treated by the combination of both family and clinic training. Patients in both control and training groups were treated by amblyopia training instrument(light brush, red flash, grating, etc.)and fine stimulation training via computer software. Additionally, patients in the training group, whose corrected vision improved more than 0.6, were also exposed to other treatments including monocular adjustment function training, disinhibition training, binocular adjustment function training, binocular integration and fusion function training. Visual acuity and outcomes were statistically analyzed after 6mo.

RESULTS: No significant difference in the total effective rate of vision improvement between the two groups. However, the overall visual acuity difference between the two groups was statistically significant(P<0.05). After disinhibition and visual function training, the number of patients with improvement in both far and near stereopsis in the training group was significantly greater than that in the control group(P<0.05).

CONCLUSION: Combinational treatment with disinhibition and binocular visual function training enhances the competitiveness of amblyopic eyes and eliminate inhibition, which is accompanied by improved visual acuity and ameliorated visual function in children patients with anisometropic amblyopia.