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[摘要]
目的：探究无早产儿视网膜病变的早产儿早期眼轴长度(axial length，AL)，分析AL与性别、胎龄、矫正胎龄、出生体质量及其它眼部生物学参数的相关性。
方法：选取2016-03/10于西北妇女儿童医院眼科筛查的无早产儿视网膜病变的早产儿400例800眼作为研究对象，对出生后4～6wk内首次检查所获得的AL等相关数据进行分析。
结果：本研究纳入早产儿400例800眼，右眼和左眼AL分别为16.11±0.58、16.13±0.53mm，差异无统计学意义(P>0.05)，故以双眼AL的平均值作为该组受检者的AL即16.12±0.55mm。本研究中，不同性别早产儿AL差异无统计学意义(P>0.05)。Pearson相关分析表明，AL与胎龄、出生体质量、矫正胎龄、前房深度、玻璃体腔长度均呈正相关(r=0.427、0.401、0.635、0.691、0.878，均P<0.01)，与晶状体厚度呈负相关(r=-0.153，P<0.01)。将上述因素纳入多元线性回归分析发现，AL与胎龄、前房深度、玻璃体腔长度具有显著相关性，得出回归方程Y=4.109+0.029X1+0.481X2+0.978X3(Y=AL，X1=胎龄，X2=前房深度，X3=玻璃体腔长度)。
结论：无早产儿视网膜病变的早产儿早期平均AL为16.12±0.55mm，且其与性别无关，与胎龄、出生体质量、矫正胎龄、前房深度、玻璃体腔长度均呈正相关，与晶状体厚度呈负相关。
[Key word]
[Abstract]
AIM: To investigate the axial length(AL)of normal premature infants, and to analyze the associations with gender, gestational age, birth weight, and postmenstrual age and other ocular biometry parameters.
METHODS: To analyze AL and other relevant data obtained from the first examination within 4-6wk after birth, 400 cases(800 eyes)of normal preterm infants were included who were screened for retinopathy of prematurity(ROP)in Department of Ophthalmology of Northwest Women and Children Hospital from March 2016 to October 2016.
RESULTS: Totally 400 cases(800 eyes)of normal preterm infants were included in this study, while the AL of right and left eyes were respectively 16.11±0.58mm and 16.13±0.53mm, with no statistically significant difference(P>0.05). Therefore, the mean value(16.12±0.55mm)of the binocular AL was taken as the AL of the group. In this study, AL differences of premature infants between different genders were not statistically significant(P>0.05). Pearson correlation analysis showed that AL was positively correlated with the gestational age, birth weight, postmenstrual age, anterior chamber depth and vitreous length(r=0.427, 0.401, 0.635, 0.691, 0.878; P<0.01), and negatively correlated with lens thickness(r=-0.153, P<0.01). By incorporating the above factors into the multiple linear regression analysis, it was found that AL was significantly correlated with gestational age, anterior chamber depth, and vitreous length, and the regression equation Y=4.109+0.029X1+0.481X2+0.978X3(Y=AL, X1=gestational age, X2=anterior chamber depth, X3=vitreous length)was obtained.
CONCLUSION: In the early stage of normal premature infants, the mean AL was 16.12±0.55mm, which was not related to gender, but positively correlated with gestational age, birth weight, postmenstrual age, anterior chamber depth, and vitreous length, and negatively correlated with lens thickness.
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