目的：探讨经Topcon眼压计(non-contact tonometry，NCT)初筛高眼压的屈光不正儿童的中央角膜厚度(central corneal thickness，CCT)分布，以及NCT、Goldmann压平眼压计(Goldmann applanation tonometry，GAT)与OCULUS Corvis ST角膜生物力学分析仪(CST)所测眼压值的差异，并分析眼压和CCT的相关性。

方法：选择经NCT测量单眼或双眼眼压高于21mmHg的非青光眼屈光不正儿童39例78眼，用CST和GAT再次进行眼压测量，两种仪器的测量顺序随机，同时用CST测量CCT并根据CCT进行眼压校正。根据CCT分成正常组和较厚组，分析经NCT初筛高眼压的屈光不正儿童的总体CCT分布情况，探讨三种仪器所测眼压值的不同及其与CCT的相关性。

结果：正常CCT组，CST低于GAT和NCT的眼压测量值，差异有统计学意义(F=5.12，P=0.01)； 较厚组，三种眼压测量方式的眼压测量值比较，差异均有统计学意义(F=15.72，P<0.001)。NCT和GAT眼压值与CCT呈明显正相关(r_NCT=0.298，P_NCT=0.04； r_GAT=0.408，P_GAT= 0.01)； CST校正眼压值与CCT无明显相关性(r_CST=0.062，P_CST=0.593)。

结论：NCT初筛高眼压的屈光不正儿童的CCT偏厚，CST校正眼压低于NCT和Goldmann眼压，NCT和GAT所测眼压与CCT呈正相关； 对于CCT偏厚的儿童患者，CST校正眼压比NCT和GAT更接近于真实眼压值。

AIM: To investigate the central corneal thickness(CCT)distribution of the children with ametropia in the non-contact tonometry(NCT), and the different intraocular pressure(IOP)measurements with Goldmann applanation tonometry(GAT)and the OCULUS Corvis ST(CST)corneal biomechanical analyzer, meanwhile, to evaluate the correlation between IOP and CCT.

METHODS: NCT was used to measure 39 children(78 eyes)of non-glaucomatous ametropia with single eye or binocular IOP higher than 21 mmHg. The IOP was measured again with CST and GAT. The two instruments were measured in random order and the CCT was measured by CST and corrected the IOP according to the CCT. The eyes were divided into the normal group and the thicker group according to the CCT. The three IOP values were analyzed by the ANOVA, and the IOP and CCT was analyzed by the Pearson correlation coefficient.

RESULTS: In the normal CCT group, the IOP by CST was lower than that the GAT and NCT measurements and the difference was statistically significant(F=5.12, P=0.01). In the thicker group, the comparison of the three intraocular pressure measurement methods was statistically significant(F=15.72, P<0.001). IOP by NCT and GAT were significantly correlated with CCT(r_NCT=0.298, P_NCT=0.04; r_GAT=0.408, P_GAT=0.01). There was no significant correlation between CST corrected intraocular pressure and CCT(r_CST=0.062, P_CST=0.593).

CONCLUSION: The CCT of ametropia children with high IOP by Topcon tonometry were thicker. The corrected intraocular pressure of CST is lower than NCT and GAT. NCT and GAT were positively correlated with CCT. For children with thicker CCT, CST corrects intraocular pressure was closer to the real intraocular pressure value than NCT and GAT.

海南省自然科学基金项目资助(No.817366)