玻璃体腔注射康柏西普治疗湿性年龄相关性黄斑变性的早期mfERG变化

Early multifocal electroretinography findings after intravitreal Conbercept in the treatment of wet age-related macular degeneration

摘要:

目的：利用多焦视网膜电图(mfERG)评价玻璃体腔注射康柏西普的湿性年龄相关性黄斑变性(age-related macular degeneration，ARMD)患者视网膜功能的早期变化。

方法：经眼底荧光血管造影确诊为湿性ARMD患者接受玻璃体腔注射康柏西普眼用注射液(0.05mL/0.5mg)，记录注射前及注射后1mo的最佳矫正视力及mfERG各环N1、P1波潜伏期及P1波振幅密度。

结果：共20例20眼患者纳入研究，平均LogMAR视力从注射前0.80±0.48提高到注射后0.65±0.50(P<0.001)，环1平均振幅密度从注射前39.59±16.60nV/deg²提高到注射后的53.81±20.41nV/deg²(P=0.006)，振幅密度的改变与视力的改变呈正相关(r=-0.776，P<0.001)。

结论：对于湿性ARMD患者玻璃体腔注射康柏西普短期内能改善黄斑中心凹的功能。

Abstract:

AIM: To evaluate the early changes of retinal function in patients with wet age-related macular degeneration(ARMD)after intravitreal Conbercept treatment by multifocal electroretinography(mfERG).

METHODS: Wet ARMD patients diagnosed by fundus fluorescein angiography and received intravitreal injection of Conbercept(0.05mL/0.5mg)were included. Best corrected visual acuity(BCVA), incubation of N1, P1 and amplitude of P1 in mfERG test were recorded before and 1mo after treatment.

RESULTS: Twenty patients(20 eyes)were enrolled in total. The mean BCVA was 0.80±0.48 LogMAR at baseline and improved to 0.65±0.50 LogMAR after treatment(P<0.001). Mean P1 amplitude density of the mfERG Ring 1 increased from 39.59±16.60nV/deg² to 53.81±20.41nV/deg²(P=0.006). The change in visual acuity was positively correlated with the change in P1 amplitude density of Ring 1(r=-0.776, P<0.001).

CONCLUSION: Intravitreal conbercept injection can improve the central retinal function of wet ARMD patients in the short term.