目的：对比观察角膜塑形镜、低浓度阿托品与框架眼镜控制青少年近视发展的疗效。

方法：选取2016-1/2016-07我科收治的青少年近视患者120例240眼，采取自愿原则分为3组：角膜塑形镜组40例80眼、低浓度阿托品组40例80眼、框架眼镜组40例80眼。随访18mo，对比分析三组患者的屈光度及眼轴变化情况。

结果：治疗18mo后，角膜塑形镜组、低浓度阿托品组的屈光度均低于框架眼镜组(P<0.05)； 角膜塑形镜组、低浓度阿托品组治疗前后屈光度差值均低于框架眼镜组(P<0.05)，但角膜塑形镜组与低浓度阿托品组比较，差异无统计学意义(P>0.05)。治疗18mo后，角膜塑形镜组、低浓度阿托品组眼轴均低于框架眼镜组(P<0.05)； 角膜塑形镜组、低浓度阿托品组治疗前后眼轴差值均低于框架眼镜组(P<0.05)，但角膜塑形镜组与低浓度阿托品组比较，差异无统计学意义(P>0.05)。

结论：角膜塑形镜与低浓度阿托品均可有效控制青少年近视患者屈光度和眼轴长度进展，其疗效均优于框架眼镜，但角膜塑形镜与低浓度阿托品控制近视的疗效无明显差异。

METHODS: A total of 120 juvenile patients(240 eyes)with mild to moderate myopia were chosen in our hospital from January 2016 to July 2016. They were divided into 3 groups voluntarily. Children in orthokeratology group(40 cases, 80 eyes)were treated with orthokeratology; children in low concentration atropine group(40 cases, 80 eyes)were treated with low concentration atropine; children in frame glasses group(40 cases, 80 eyes)were treated with frame glasses. After 18mo follow-up, refractive degree and ocular axial length of three groups were statistically analyzed.

RESULTS: After 18mo, diopters of children in orthokeratology group and atropine group were lower than those of children in frame glasses group(P<0.05). The diopter differences between before and after treatment of orthokeratology group and atropine group were lower than that of the frame glasses group(P<0.05), there was no significant differences between orthokeratology group and atropine group(P>0.05). The axial growth of children in orthokeratology group and atropine group were lower than those of children in frame glasses group(P<0.05). The axial length differences between before and after treatment of orthokeratology group and atropine group were lower than that of the frame glasses group(P<0.05); there was no significant differences between orthokeratology group and atropine group(P>0.05).

CONCLUSION: Both orthokeratology and low concentration atropine can effectively control the progress of diopter and axial length in juvenile myopia, and their curative effects were better than frame glasses. During the 18mo observation period, the curative effects of orthokeratology and atropine have no significant differences.