正常人外层视网膜厚度随年龄增长的相关性分析

Changes of outer retinal thickness with increasing age in normal eyes

摘要:

目的：研究正常人外层视网膜厚度和年龄的关系。

方法：回顾分析100例100眼健康人的频域光学相干断层扫描的图像，测量黄斑区及四个象限下列项目的距离：内界膜到内外节连接体(ELM-IS/OS)，内外节连接体到视锥细胞外节段(IS/OS-COST)，视锥细胞外节段到色素上皮复合体(COST-RPE)和视网膜外层全层(RT)。分析各层厚度和年龄、性别的关系。

结果：女性RT比男性薄(男：234.47±16.79 μm； 女： 223.13±15.43 μm)。鼻侧视网膜外层全层、中心凹及四个象限处ELM-IS/OS的厚度与年龄呈显著负相关。中心凹及四个象限处IS/OS-COST和COST-RPE厚度与年龄、性别均无显著相关性。中心凹处RT厚度比其余象限显著变薄； ELM-IS/OS、 IS/OS-COST和COST-RPE中心凹处相比其余四象限厚度增厚。

结论：在正常眼中，鼻侧RT厚度和ELM-IS/OS厚度随年龄增长显著变薄，IS/OS-COST和COST-RPE厚度不随年龄及性别变化而变化。

Abstract:

AIM:To comprehensively investigate the relationship between outer retinal layer thickness and age in normal eyes.

METHODS: One hundred normal eyes of 100 subjects who underwent spectral-domain optical coherence tomography(SD-OCT)were included in this retrospective study. The distances between the external limiting membrane(ELM)line and the photoreceptor inner segment/outer segment(IS/OS)line(ELM-IS/OS), the IS/OS line and the cone outer segment tips(COST)line(IS/OS-COST), the COST line and the retinal pigment epithelium(RPE)complex(COST-RPE)and the full retinal thickness(RT)were measured at the fovea and on four quarters. The relationship between thickness and age or sex was then analysed.

RESULTS: A thinner RT was observed in women in a multiple regression analysis(men: 234.47±16.79 μm; women: 223.13±15.43 μm). The RT on the nasal quarter and the ELM-IS/OS thickness at the fovea and on the four quarters were significantly and negatively correlated with age. The IS/OS-COST and COST-RPE thicknesses at the fovea and on the four quarters were not significantly correlated with age or sex, respectively. The RT at the fovea was significantly thinner than on the four quarters. The ELM-IS/OS, IS/OS-COST and COST-RPE thicknesses at the fovea were significantly thicker than on the four quarters.

CONCLUSION: In normal eyes, the RT thickness on the nasal quarter and the ELM-IS/OS thickness were significantly and negatively correlated with age. The IS/OS-COST and COST-RPE thicknesses were not significantly correlated with age or sex.