[关键词]
[摘要]
糖尿病视网膜病变(diabetic retinopathy，DR)是糖尿病(diabetic melitus，DM)常见且严重的微血管并发症之一。在国外，DR是工作人群(20～64岁)首位的致盲因素； 在国内，DR的发病率和致盲率也在逐年增加，严重影响患者的生存质量。以往对DR发病机制和治疗的研究主要集中在微血管方面，近年来，随着研究的深入，越来越多的学者认为DR不再单纯是一种微血管病变，同时伴随着视网膜神经退行性改变，但国内外文献对DR的微血管病变与神经退行性改变发病机制的研究多是单一的。本文就DR微血管病变与神经退行性改变之间的关系做一综述。
[Key word]
[Abstract]
Diabetic retinopathy is one of the common and serious microvascular complications of diabetes. In foreign countries, DR is the leading cause of blindness in the working age group(20-64 years). In China, the incidence of DR and the rate of blindness increase year by year, which seriously affects the patients' quality of life. Previous studies on the pathogenesis and treatment of diabetic retinopathy were mainly focused on the microvascular; in recent years, with the deepening of researches, more and more scholars believe that DR is no longer simply a kind of microangiopathy, but is also accompanied by retinal neurodegeneration. However, studies on the pathogenesis of microvascular disease and neurodegenerative changes of diabetic retinopathy in the literature domestic and abroad are mostly single. This article reviews the relationship between microvascular disease and neurodegenerative changes in diabetic retinopathy.
[中图分类号]
[基金项目]
牡丹江医学院研究生创新科研项目(No.2017YJSCX-28MY)
