目的：虹膜色素剥脱综合征(XFS)和剥脱性青光眼(XFG)患者与对照组血清维生素D水平比较。

方法：使用液相色谱法测量25羟基维生素D血清水平。记录性别、年龄、高血压、糖尿病和缺血性心脏病病史等可变因素。

结果：研究包括55例 XFS/XFG 患者和正常对照组60例。XFS/XFG 患者较为年长(平均年龄：71.8y vs 67.5y， P=0.002)。两组性别分布相似且糖尿病、高血压和缺血性心脏病的患病率无显著性差异。XFS/XFG 患者平均维生素D水平为14.7 ng/mL，正常对照组为14.9 ng/mL，两组间无显著性差异。虽然XFS/XFG 组维生素D水平较低，但在对年龄、性别和医疗条件进行校正后，多变量分析显示两组之间维生素D缺乏无显著差异。

结论：XFS/XFG 组和正常对照组维生素D水平均较低，而XFS/XFG 组低于正常对照组，两组间无明显差异。XFS和维生素D缺乏症与某些系统性疾病有共同联系。

METHODS: Serum levels of 25-hydroxy Vitamin D(Vitamin D)were measured using liquid chromatography. Variables like age, sex and medical history of hypertension, diabetes mellitus and ischemic heart disease were reported.

RESULTS: This study included a total of 55 patients with XFS/XFG and 60 control subjects. Patients with XFS/XFG were significantly older than control subjects(mean age: 71.8y vs 67.5y, P=0.002). Gender distribution was similar. The prevalence rates of diabetes, hypertension, and ischemic heart disease were not significantly different between the two groups. The mean of Vitamin D was 14.7 ng/mL for patients with XFS/XFG and 14.9 ng/mL for control subjects with no significant difference. Although Vitamin D level was lower in the XFS/XFG group but multivariate analysis did not show significant difference in Vitamin D deficiency between the two groups after adjusting for age, gender, and medical conditions.

CONCLUSION: The outcomes of our study are different from those in the literature. Vitamin D levels were low in both the XFS/XFG group and the control group being lower in the first one but that difference was not statistically significant. XFS and Vitamin D deficiency share common associations with certain systemic diseases. Further studies with larger numbers are needed to elaborate more on these associations and to support further the controversial literature.