目的：分析泪膜破裂时间(break-up time，BUT)与全身因素的关系。

方法：收集2015-01/2016-07于福州总医院体检中心的体检者或住院患者共747例747眼，所有纳入研究者均测量收缩压、舒张压、血糖、总胆固醇、高密度脂蛋白、低密度脂蛋白、BUT等值。采用SPSS19.0对BUT与全身因素的关系进行简单及多重线性回归分析。

结果：简单线性回归分析结果可见，舒张压与BUT呈正相关(P<0.05)，年龄、收缩压、血糖、胆固醇、高密度脂蛋白、低密度脂蛋白与BUT呈负相关(P<0.05)，而甘油三酯与BUT无相关性(P=0.227)。多重线性回归分析提示，BUT与舒张压(P<0.001)呈正相关，而与收缩压(P<0.001)、血糖(P<0.001)、高度密度脂蛋白(P=0.019)呈负相关。BUT与年龄、胆固醇、甘油三酯、低密度脂蛋白无相关性。

结论：在所有参与研究的指标中，血糖与BUT的相关性最为显著，提示在临床研究中糖尿病患者的眼表损害。

METHODS: From January 2015 to July 2016 in the medical examination center of Fuzhou General Hospital or hospitalized, there were 747 cases included. All participants were observed for systolic and diastolic blood pressure, blood glucose, total cholesterol, high density lipoprotein cholesterol, low density lipoprotein, break-up time equivalent. The relationship between tear film rupture time and systemic factors was analyzed with simple and multiple linear regression analysis by SPSS19.0.

RESULTS: Simple linear regression analysis results showed that the diastolic pressure and tear break-up time were positively correlated(P<0.05); age, systolic blood pressure, blood glucose, cholesterol, high density lipoprotein, low density lipoprotein was negatively correlated with BUT(P<0.05), but no correlation between triglyceride and tear film break up time(P=0.227). Multiple linear regression analysis suggested that the tear film rupture time was positively correlated with diastolic blood pressure(P<0.001), but negatively correlated with systolic blood pressure(P<0.001), blood glucose(P<0.001)and high-density lipoprotein(P=0.019). The time of tear film rupture was not related to age, cholesterol, triglyceride, low density lipoprotein.

CONCLUSION: The correlation between blood glucose and tear film BUT is the most significant among all the indexes involved, indicating that ocular surface damage may occur in diabetic patients.