目的：探讨羟苯磺酸钙联合全视网膜激光光凝治疗重度非增殖性糖尿病视网膜病变(non-proliferative diabetic retinopathy patients，NPDR)的疗效。

方法：收集2014-12/2017-04我院收治的重度NPDR患者92例184眼，经随机数表法分为激光组、联合治疗组各46例92眼。激光组接受全视网膜激光光凝治疗，联合治疗组接受羟苯磺酸钙联合全视网膜激光光凝治疗。对比两组患者的疗效及眼底检测参数、视网膜微循环参数水平差异。

结果：治疗7wk后，联合治疗组患者的治疗有效率高于激光组，差异有统计学意义(P<0.01)； 联合治疗组的眼底检测参数视网膜电图震荡电位OS2波幅(Ops OS2)、黄斑中心凹下脉络膜厚度(SFCT)水平高于激光组，差异有统计学意义(P<0.01)； 联合治疗组的视网膜微循环参数峰值血流速度(PSV)、平均血流速度(MV)的水平高于激光组，阻力指数(RI)、搏动指数(PI)的水平低于激光组，差异有统计学意义(P<0.01)。

结论：重度NPDR患者接受羟苯磺酸钙联合全视网膜激光光凝治疗，可有效提升整体疗效，改善眼底结构及视网膜微循环状态。

METHODS:A total of 92 patients(184 eyes)with severe NPDR were collected in our hospital from December 2014 to April 2017, and divided into laser group and combined treatment group by random number table method. The laser group was treated with panretinal laser photocoagulation, and the combined treatment group received calcium dobesilate combined with retinal laser photocoagulation. The effect of the two groups was compared on the retinal microcirculation parameters.

RESULTS: Seven weeks after treatment, treatment effective rate in combined treatment group was higher than that in laser group(P<0.01). Fundus examination parameter such as Ops OS2, subfoveal choroid thickness(SFCT)in combined treatment group were higher than those in laser group(P<0.01). Retinal microcirculation parameters such as PSV, MV in combined treatment group were higher than the level of the laser group, RI, PI levels were lower than those in laser group(P<0.01).

CONCLUSION: Calcium dobesilate combines with panretinal photocoagulation in severe NPDR patients can effectively improve the overall effect and optimize the fundus structure and retinal microcirculation.