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[摘要]
目的：比较扫频CASIA SS-1000 OCT与Sirius眼前节分析仪两种仪器测量正常人角膜顶点厚度(CCT)和最薄点角膜厚度(TCT)结果的差异性、相关性及一致性，为临床的应用提供理论依据。
方法：前瞻性研究。收集近视患者34例，均由同一熟练操作者对受检者右眼进行测量，先采用Sirius眼前节分析仪，再使用SS-1000 OCT重复测量角膜厚度。配对t 检验及Bland-Altman 用于评估SS-1000 OCT 与Sirius眼前节分析仪的角膜顶点及角膜最薄点的一致性。
结果：SS-1000 OCT 及Sirius角膜地形图仪测量CCT 的角膜顶点均值分别为517.62±25.29、518.47±27.23μm。SS-1000 OCT 及Sirius眼前节分析仪CCT 的角膜最薄点均值分别为513.53±25.06、515.32±26.69μm。两者角膜顶点角膜厚度比较，差异无统计学意义(P>0.05)，但两者角膜最薄点的角膜厚度比较，差异具有统计学意义(P<0.05)。两种设备测量的角膜厚度有较好的相关性(r=0.969、0.965，均P<0.05)。做Bland-Altman分析，角膜顶点厚度的95%一致性界限为(-14.22μm，12.52μm)，角膜最薄点厚度的95%一致性界限为(-15.61μm，12.03μm)，4%(3/68)的点在95%一致性的界限外，但角膜最薄点的一致性差异更大。
结论：SS-1000 OCT 测量CCT与Sirius眼前节分析仪具有高度的一致性，在临床工作中，可以考虑相互替代，但角膜最薄点还不能相互替代。
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[Abstract]
AIM: To compare CASIA SS-1000 and Sirius OCT sweep anterior segment analyzer instrument for measuring normal corneal vertex thickness(CCT)and the thinnest corneal thickness(TCT)results the difference, correlation and consistency, and provide a theoretical basis for clinical application.
METHODS: This was a prospective study. A total of 34 normal subjects were collected. The subjects were measured by the same skilled operator. The SS-1000 OCT was first used, and then the corneal thickness was measured repeatedly by Sirius anterior segment analyzer. Paired t test and Bland-Altman were used to evaluate the consistency of corneal apex and corneal thinnest point between SS-1000 OCT and Sirius anterior segment analyzer.
RESULTS: The mean corneal apex measured by SS-1000 OCT and Sirius corneal topography were 517.62±25.29μm and 518.47±27.23μm CCT, respectively. The thinnest points of SS-1000 OCT and Sirius anterior segment analyzer CCT were 513.53±25.06μm and 515.32±26.69μm, respectively. Paired t test showed that the difference on corneal thickness of vertex was not statistically significant(P>0.05), but the thinnest corneal thickness was statistically significant(P<0.05). Pearson analysis of the two devices, the correlation is 0.969, 0.965. The results of 95% consistency limiting analysis on the corneal vertex thickness by Bland-Altman was(-14.22μm, 12.52μm), that of the thinnest corneal thickness was(-15.61μm, 12.03μm), 4%(3/68)was out of the 95% consistency limiting, but the thinnest corneal thickness was of a little larger differences.
CONCLUSION: SS-1000 OCT measurement of CCT and Sirius anterior segment analyzer is highly consistent, in clinical work can be considered alternative, but the thinnest point of the cornea can not be replaced each other.
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