[关键词]
[摘要]
目的：观察不同分期糖尿病性视网膜病变(diabetic retinopathy，DR)视网膜动、静脉循环时间的差异性，分析各期DR视网膜血管循环时间的变化特点。
方法：收集2016-03/2017-03我院眼科确诊的DR患者60例60眼，其中轻中度非增殖期糖尿病视网膜病变(nonproliferative diabetic retinopathy，NPDR)组20例20眼、重度NPDR组20例20眼、增殖期糖尿病视网膜病变(proliferative diabetic retinopathy，PDR)组20例20眼。通过眼底荧光血管造影(undus fluorescein angiography，FFA)检查记录视网膜动脉4个分支主干刚开始显影即臂视网膜循环时间(A1)和完全充盈的时间(A2)、视网膜静脉4个分支主干全部出现层流的时间(V1)和完全充盈的时间(V2)，并进行相关分析。
结果：视网膜动脉通过时间(A2-A1)三组比较，差异无统计学意义(F=1.642，P=0.157)。视网膜毛细血管通过时间(V1-A2)、视网膜静脉通过时间(V2-V1)、视网膜动静脉通过时间(V2-A1)三组分别比较，差异均有统计学意义(F=5.794、5.180、5.564，P=0.007、0.009、0.008)，其中PDR组均较轻中度和重度NPDR组明显延长，重度NPDR组均较轻中度NPDR组明显延长。
结论： DR病程越长，程度越重，视网膜微血管破坏越严重，视网膜微循环时间越长。
[Key word]
[Abstract]
AIM: To observe whether differences exist in the retinal arteriovenous circulation time of the patients with diabetic retinopathy and exploring whether there is any correlation between the injured degree of retinal vessel and the microcirculation time.
METHODS: The study was conducted from the March 2016 to the March 2017 in order to analyze the clinical data on 60 eyes of 60 patients who were diagnosed with diabetic retinopathy by Xuanwu Hospital of Capital Medical University.According to the result, patients were divided into mild and moderate nonproliferative diabetic retinopathy(NPDR)group, severe NPDR group and proliferative diabetic retinopathy(PDR)group with 20 eyes respectively. Then we recorded the retinal arterial developing time of the three groups, namely arm-to-retinal circulation time(A1),retinal arterial branch filling time(A2), retinal venous branch laminar flow time(V1), retinal venous branch filling time(V2).
RESULTS: The findings showed that there was no statistical difference among 3 groups in the retinal arterial passage time(A2-A1)(F=1.642, P=0.157). Retinal capillary passage time(V1-A2), retinal vein passage time(V2-V1), retinal artery and vein passage time(V2-A1)were compared between the three groups, the difference was statistically significant(F=5.794, 5.180, 5.564, P=0.007, 0.009, 0.008). The PDR group was significantly longer than the mild moderate and severe NPDR group, and the severe NPDR group was significantly longer than the mild and moderate NPDR group.
CONCLUSION: The duration of DR is longer, the degree is more severely. The destruction of retinal capillaries is more serious, the time of retinal microcirculation is longer.
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