目的：探讨飞秒激光辅助LASIK制瓣术中发生前房气泡的影响因素和处理方法。

方法：飞秒激光辅助LASIK手术患者4 859例9 671眼，回顾性分析比较其中发生前房气泡眼的术前、术中及术后各参数。

结果：患者51眼发生前房气泡，发生率为0.53%。术后1mo裸眼视力(-0.076±0.09)与术前最佳矫正视力(-0.08±0.04)相比差异无统计学意义(t=-0.34，P=0.74)。33眼(65%)不影响瞳孔跟踪，18眼(35%)在去红外跟踪模式下完成手术。跟踪组(31例33眼)术后1mo裸眼视力为-0.06±0.08，去跟踪组(18例18眼)术后1mo裸眼视力为-0.11±0.09，两组相比差异无统计学意义(t=1.82，P=0.07)。前房气泡在角膜缘9：00位发生率最高，其次为3：00位。其中47例双眼手术单眼发生前房气泡，发生前房气泡眼与其对侧眼各参数(术前等效球镜、角膜曲率、角膜直径、前房容积、前房深度、前房角度和术中飞秒激光能量等)差异均无明显统计学意义(P>0.05)。

结论：前房气泡是飞秒激光辅助LASIK手术中少见的并发症，会干扰准分子激光切削时的眼球跟踪，如术中妥善处理对术后早期视力无明显影响。发生前房气泡的直接或间接因素尚不清楚。

METHODS: Totally 9 671 eyes of 4 859 patients with femtosecond LASIK were included in this study. Preoperative, intraoperative and postoperative parameters of anterior chamber gas bubble patients were analyzed and compared.

RESULTS: A total of 51 cases(0.53%)occurred anterior chamber gas bubble during femtosecond flap creation. There was no statistical difference between uncorrected visual acuity of postoperative 1mo(-0.076±0.09)and preoperative best corrected visual acuity(-0.08±0.04; t=-0.34,P=0.74). And 33 eyes(65%)did not affect the pupil tracking, but there were 18 eyes(35%)unable to track the pupil successfully. There was no statistical difference in uncorrected visual acuity of postoperative 1mo between trace group(-0.06±0.08)and no trace group(-0.11±0.09; t=1.82, P=0.07). The highest incidence of anterior chamber gas bubble was at 9 point, followed by 3 point. There were no statistical differences in spherical equivalent refraction, corneal curvature, corneal diameter, anterior chamber volume, anterior chamber depth and intraoperative femtosecond laser energy between anterior chamber gas bubble eyes and the contralateral eyes(P>0.05).

CONCLUSION: Anterior chamber gas bubble formation during femtosecond flap creation for LASIK is an uncommon event. It may affect the eye tracking. There is no obvious effect on early postoperative visual acuity if intraoperative disposed properly. The direct or indirect factors of anterior chamber gas bubble formation are unclear.