白藜芦醇在年龄相关性眼病中的研究进展

Research progress on the role of resveratrol in age-related eye diseases

摘要:

年龄相关性眼病是指随着年龄增长，由眼退行性改变引起的一系列眼科疾病，青光眼、白内障和年龄相关性黄斑变性(age-related macular degeneration，AMD)是常见的几种年龄相关性眼病，炎症反应和氧化应激在其发病过程中扮演着重要角色。白藜芦醇是一种天然植物抗毒素，通过调节多个细胞转导通路发挥抗氧化应激、抗炎作用，已成为抗衰老领域的研究热点，并取得了较大进展。目前，白藜芦醇与年龄相关性眼病的研究仍处于初始阶段，本文重点介绍白藜芦醇在年龄相关性眼病中的最新研究进展。

Abstract:

Age-related eye diseases are a set of ophthalmic diseases caused by aging and irreversible degeneration in the eye. Glaucoma, cataract, and age-related macular degeneration(AMD)are some of the common age-related eye diseases. Inflammation and oxidative stress play important roles in the initiation and progression of these diseases. Resveratrol, a natural plant antitoxin, fights oxidative stress and inflammation by regulating multiple cellular transduction pathways; and it has become a focal point in anti-aging research and has seen significant research progress during recent years. At the present, investigation into the relationship between resveratrol and age-related eye diseases is still in its infancy. This paper focuses on elaborating new research progress on resveratrol's role in age-related eye diseases.