目的：分析不同阶段青光眼患者血清炎症因子表达水平变化及临床意义。

方法：选取2014-01/2016-08我院收治的原发性开角型青光眼患者70例128眼，按照视野平均缺损程度分为轻(观察1组)、中(观察2组)、重(观察3组)三组，另选取同期在我院接受治疗白内障患者65例130眼作为对照组。观察并对比青光眼患者血清炎症因子表达水平。

结果：两组患者血清IL-2和IFN-γ水平比较，差异无统计学意义(P>0.05)。青光眼组患者sIL-2R和IL-4水平均高于对照组患者，IL-6和IL-12水平均低于对照组患者(P<0.05)。青光眼组患者眼压和近视比例均高于对照组患者，差异有统计学意义(P<0.05)。各组患者中度近视和重度近视比例比较，差异无统计学意义(P>0.05)。观察3组患者低度近视比例少于观察1组和观察2组患者(P<0.05)。观察1组和观察2组患者IL-2、sIL-2R、IL-4、IL-6及IFN-γ水平比较，差异无统计学意义(P>0.05)。观察3组患者sIL-2R水平高于观察1组患者，IL-12水平低于观察1组和观察2组患者(P<0.05)。青光眼组患者间IL-2、IL-4、IL-6及IFN-γ水平比较，差异无统计学意义(P>0.05)。观察3组患者眼压水平和近视比例均高于观察1组和观察2组患者，差异有统计学意义(P<0.05)。观察2组患者眼压高于观察1组患者(P<0.05)。观察1组和观察2组患者近视比例比较，差异无统计学意义(P>0.05)。

结论：原发性开角型青光眼患者血清IL-12、sIL-2R和眼压水平在神经损伤不同阶段波动明显，说明免疫应答反应和眼压高低参与视神经损伤的过程。

METHODS:Totally 70 cases of 128 eyes with primary open-angle glaucoma in our hospital from January 2014 to August 2016 were selected. According to the mean defect of visual field, they were divided into light(observation Group 1), moderate(observation Group 2)and heavy group(observation Group 3). Another 65 cases of 130 eyes with cataract were taken as the control group in our hospital. The observation and expression of serum cytokines in these patients with glaucoma were taken.

RESULTS: There was no significant difference in serum IL-2 and IFN- γ levels between the two groups(P>0.05). The sIL-2R and IL-4 levels in the glaucoma group were higher than those in the control group, and the levels of IL-6 and IL-12 were lower than those of the control group(P<0.05). The IOP and proportion of myopia in the glaucoma group was higher than that in the control group, the difference was not statistically significant(P<0.05). The ratio of moderate myopia to severe myopia in each group was not statistically significant(P>0.05). To observe the low myopia ratio in Group 3 of patients, it was less than observation Group 1 and observation Group 2(P>0.05). There was no statistically significant difference between observation Group 1 and 2 of patients on IL-2, sIL-2R, IL-4, IL-6 and IFN-γ levels(P>0.05). The level of sIL-2R in the Group 3 was higher than that in the Group 1, and the level of IL-12 was lower than that in the Group 1 and in the Group 2(P<0.05). There was no significant difference in IL-2, IL-4, IL-6 and IFN-γ levels between the glaucoma patients(P>0.05). The IOP level and the proportion of myopia in the Group 3 were higher than those in the Group 1 and the Group 2 were observed, the difference was statistically significant(P<0.05). The intraocular pressure was higher in Group 2 than in group 1(P<0.05). There was no statistically significant difference on proportion of myopia between observation Group 1 and observation Group 2(P>0.05).

CONCLUSION: The levels of serum IL-12, sIL-2R and intraocular pressure in patients with primary open-angle glaucoma fluctuated significantly at different stages of the nerve injury, indicating that the immune response and intraocular pressure were involved in the process of optic nerve damage.