青光眼患者房水中细胞因子的研究进展

Research progress of cytokines in aqueous humor of patients with glaucoma

摘要:

房水由睫状突上皮细胞产生，是前房的重要组成部分，为角膜、晶状体、小梁网等无血管组织提供营养。相较于血液，房水能更好地反映眼内的环境，因此近几年房水中细胞因子检测成为眼科研究的热点之一。研究者已经在多种眼部疾病中发现了房水细胞因子的改变，包括青光眼。一些研究认为，房水中细胞因子的改变可能与青光眼的发病机制有关，甚至可能影响青光眼滤过术的预后。本文总结了几类细胞因子在青光眼房水中的变化，并分析它们与青光眼的关系。

Abstract:

Aqueous humor is the product of the ciliary body. It provides nutrition for the iris, cornea, lens, and trabecular meshwork. Compared to the blood, the aqueous humor can better reflect the intraocular environment. Therefore, the detection of cytokines in the aqueous humor has become one of the hot topics in ophthalmology in recent years. Altered cytokine levels in the aqueous humor have been observed in many ocular diseases, including glaucoma. Some investigators hypothesized that cytokines in the aqueous humor are associated with the pathophysiology of glaucoma, and even affect the prognosis of glaucoma filtering surgery. In this paper, the changes of several cytokines in the aqueous humor of glaucoma eyes were summarized, and the relationship between them was analyzed.