[关键词]
[摘要]
长链非编码RNA(long non-coding RNA，LncRNA)是一类不编码蛋白质的转录子，长度大于200个核苷酸，主要在表观遗传、转录或转录后水平调节基因的表达。LncRNA的表达异常可能引发各种病理过程。糖尿病视网膜病变(diabetic retinopathy，DR)为多因素疾病，新近的研究表明，许多LncRNA特异表达与DR的发生密切相关。在本文中，我们对LncRNA的相关功能、参与DR发生发展的调控机制以及相关治疗的新近研究进行综述。
[Key word]
[Abstract]
Long non-coding RNA(LncRNA)is a class of transcript(>200 nucleotides)that do not encode proteins. It plays an important role in epigenetic regulation and gene expression at transcriptional or post transcriptional level. The abnormal expression of LncRNA may lead to various pathological processes. Diabetic retinopathy(DR)is a multifactorial disease. Recent studies have shown that many specific expressions of LncRNAs are closely related to the genesis of DR. In this review, we summarized the recent advances in the function of LncRNA, the regulatory mechanisms of LncRNA involved in the development of DR, and the related therapies.
[中图分类号]
[基金项目]
国家自然科学基金资助项目(No.81470618); 黑龙江省自然科学基金资助项目(No.H2016038); 黑龙江省博士后科研启动金资助(No.LBH-Q15102)
