方法：选取2015-02/12我院泪道阻塞患者86例138眼，根据是否用盐酸洛美沙星眼用凝胶分成对照组43例68眼和观察组43例70眼。对照组患者给予单纯硅胶泪道引流治疗，观察组患者在对照组基础上给予盐酸洛美沙星眼用凝胶治疗。观察并比较两组患者临床总有效率、血清超敏C-反应蛋白(hypersensitive C-reactive protein，h-CRP)水平、并发症和复发率情况。

结果：观察组患者的鼻泪管阻塞、泪总管阻塞和泪小管阻塞总有效率分别为95.2%、100.0%、96.7%，均高于对照组患者(P<0.05)。两组患者术前血清h-CRP水平比较，无统计学差异(P>0.05)； 观察组患者术后3、7d时血清h-CRP水平分别为2.40±0.84、1.94±0.84μg/mL，均低于同时间点对照组患者(P<0.05)。观察组患者并发症率为1.4%，低于对照组患者(P<0.05)。随访6～18mo，观察组患者复发率为11.4%，明显低于对照组(P<0.05)。

结论：硅胶泪道引流管联合盐酸洛美沙星眼用凝胶治疗泪道阻塞的临床疗效好，可降低炎症反应，且并发症少，复发率低。

METHODS: Totally 86 cases(138 eyes)of lacrimal duct embolism treated in our hospital from February to December 2015 were divided into 43 cases(68 eyes)as control group and 43 cases(70 eyes)of the observation group according to whether they were treated with lomefloxacin hydrochloride eye ophthalmic gel. Patients in the control group were treated with silica gel drainage, while the observation group was treated with lomefloxacin hydrochloride eye ophthalmic gel on the basis of the control group. The total effective rate, serum hypersensitivity C-reactive protein(h-CRP)level, complications and recurrence rate were observed and compared between the two groups.

RESULTS: The total effective rate in the patients with obstructive nasolacrimal duct, common lacrimal duct obstruction, and lacrimal duct obstruction in observation group were 95.2%, 100.0%, 96.7%, higher than those in control group(P<0.05). There was no significant difference between the two groups in preoperative serum h-CRP levels(P>0.05). The serum levels of h-CRP in patients in the observation group at 3d and 7d after operation respectively were 2.40±0.84g/mL, 1.94±0.84g/mL, lower than those of control group at the same time(P<0.05). The complication rate of the observation group was 1.4%, which was lower than that of the control group(P<0.05). Follow up for 6-18mo, the recurrence rate was 11.4% in the observation group, which was significantly lower than the control group(P<0.05).

CONCLUSION: The combination of silica gel drainage tube and lomefloxacin hydrochloride eye ophthalmic gel in the treatment of obstruction of lacrimal duct has good clinical efficacy, low inflammatory reaction, low complication rate and low recurrence rate.