方法：对2015-06/2016-03我院收治的16例16眼真菌性角膜炎患者的临床资料进行回顾性分析。16例真菌性角膜炎进行猪角膜脱细胞基质移植，术后随访6mo。对患者术后视力、角膜植片情况、并发症及复发情况进行分析。

结果：术后7～10d植片角膜上皮化。16例病例术后1mo角膜水肿，1mo后角膜水肿消失，角膜逐渐透明。术后1mo有2例出现术眼角膜上皮缺损，药物治疗均恢复。术后出现眼压高3例，给予降眼压治疗后眼压控制。随访期间未出现角膜溶解、感染复发、排斥现象。术后1、3、6mo视力分别为1.27±0.22，1.11±0.13，0.79±0.22，术后视力均较术前明显提高，术后1mo视力与术前相比无统计学差异(P=0.06)，术后3、6mo视力与术前相比具有明显统计学差异(P=0.01、0.001)； 其中术后3mo与术后1mo视力相比无明显提高，结果无统计学差异(P=0.11)，而术后6mo视力较术后1、3mo均有明显提高，结果具有显著统计学差异(P<0.001)。

结论：猪角膜脱细胞基质移植治疗真菌性角膜炎是安全、有效的方法。

METHODS: We performed a retrospective analysis of 16 cases of fungal keratitis received the transplantation of acellular porcine corneal matrix from June 2015 to March 2016 with a follow-up of 6mo. We analyzed on items as postoperative visual acuity, corneal graft status, postoperative recurrence and postoperative complications.

RESULTS: We observed a healing time of corneal epithelium in 7 to 10d postoperatively generally and the absence of corneal edema in 1mo, while the cornea gradually returned transparent in the 16 cases. Two cases required medication for an epithelial recovery and 3 cases received intervention for decreasing intraocular pressure to a certain level. During the follow-up we observed no cases of cornea degeneration, recurrence of infection or rejection. The vision acuity showed 1.27±0.22, 1.11±0.13, 0.79±0.22 in 1, 3 and 6mo after operation respectively. There was no statistical difference between vision in 1mo and the vision before surgery(P=0.06); while we found a statistical difference when comparing the vision of 3 and 6mo with vision before surgery(P=0.01,0.001). The vision in 6mo increased with a statistic difference to the vision at 1 and 3mo(P<0.001)while no statistic difference was observed between 1 and 3mo(P=0.11).

CONCLUSION: Transplantation of acellular porcine corneal matrix is a safe and efficient treatment for fungal keratitis.