[关键词]
[摘要]
结膜杯状细胞散在分布于复层上皮中，可分泌黏蛋白来维持眼表环境稳定。有研究证明结膜杯状细胞具有分泌黏液、眼表废物清除以及免疫调节功能。本文着重阐述结膜杯状细胞的生物学特性以及对其分化起调节作用的关键性因子SPDEF(SAM pointed domain Ets factor)对该细胞功能的影响，进一步明确杯状细胞与眼健康的相关性。
[Key word]
[Abstract]
Conjunctiva goblet cells are spread out within a stratified epithelium, and keep ocular surface homeostasis by secreting mucin. Previous research has shown conjunctiva goblet cells can secret mucin, remove debris and modulate ocular surface immune function. In this review, we will focus on biological characteristics of conjunctiva goblet cells and the effect of key factors SAM pointed domain Ets factor(SPDEF)on differentiation and function of conjunctiva goblet cells, and further understand relationship between goblet cells and eye health.
[中图分类号]
[基金项目]
国家自然科学基金项目(No.81274173、81673671); 北京市自然科学基金项目(No.7122017); 首都医科大学基础与临床基金资助项目(No.2015JL55); 首都医科大学创新基金资助项目(No.xsky2015011)
