[关键词]
[摘要]
目的：比较圆锥角膜患者和正常人使用Oculus Keratograph 5M(K5M)测得的非侵入性泪膜破裂时间(NITBUT)和泪河高度(TMH)，以确定这两项指标和圆锥角膜的关系。
方法：50例100眼圆锥角膜患者和50例100眼正常人参加了这项研究。圆锥角膜组患者的年龄为15～60(平均28.33±8.60)y。对照组为18～60(平均26.25±1.11)岁。使用K5M测量所有受试者的NITBUT和TMH。
结果：两组之间的NITBUT和TMH平均值差异无统计学意义(P=0.58，0.69)。两参数的相关性研究显示，两组中NITBUT和TMH之间均无相关性(圆锥角膜组： r= 0.053， P=0.721； 对照组： r=-0.0501， P=0.7098)。
结论：研究显示圆锥角膜对泪液质量和数量都没有显著的临床影响。
[Key word]
[Abstract]
AIM: To compare the non-invasive tear break-up time(NITBUT)and tear meniscus height(TMH)measurements in keratoconus patients and normal subjects, and to determine the relationship between these measurements with keratoconus disease by the Oculus Keratograph 5M(K5M).
METHODS:Fifty keratoconus patients(100 eyes)and 50 healthy subjects(100 eyes)participated in the study. The age range in keratoconus group was 15-60(mean ± standard deviation=28.33±8.60)y, and in control group was 18-60(26.25±1.11)y. The measurements of NITBUT and TMH were performed using the K5M.
RESULTS: The mean value of NITBUT between the keratoconus group and the control group showed no statistically significant different(P=0.58). Also, the mean of TMH between two groups was not significantly different(P=0.69). The results of correlation coefficient between the variables of the study demonstrated that there was no significant relationship between the NITBUT and TMH measurements with the two groups(keratoconus group: r= 0.053, P=0.721; control group; r=-0.0501, P=0.7098).
CONCLUSION: Our study shows that the presence of keratoconus has no clinically significant impact on the quality and quantity of tear film.
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