[关键词]
[摘要]
目的:观察带角膜缘的自体结膜瓣移植术治疗翼状胬肉合并结膜囊肿患者的疗效。
方法:收集华中科技大学同济医学院附属同济医院眼科于2013-08/2015-08住院接受手术的翼状胬肉患者126例188眼,其中翼状胬肉合并区域结膜囊肿者11例11眼作为观察组,余为对照组,所有患者均行裂隙灯显微镜检查、眼前节照相、眼前节OCT检查,并采用翼状胬肉颈部宽度×遮盖角膜的长度计算翼状胬肉的大小,采取翼状胬肉切除联合带角膜缘的自体结膜瓣移植的手术方式,切除物均行病理切片HE染色观察,术后随访4~28mo。
结果:观察组术后病检结果均证实为翼状胬肉合并结膜囊肿,囊壁完整,内附单层上皮细胞。观察组翼状胬肉大小平均为6.9±1.7mm2,对照组大小平均为6.3±1.8mm2,两组间比较无统计学差异(P>0.05)。观察组术后角膜上皮愈合时间平均为2.1±0.9d,对照组术后角膜上皮愈合时间平均为1.9±0.8d,两组间比较无统计学差异(P>0.05)。随访期内观察组术后未见翼状胬肉复发,对照组术后2例2眼复发。
结论:带角膜缘的自体结膜瓣移植治疗翼状胬肉合并结膜囊肿是一种安全有效的治疗方法,结膜囊肿术后对翼状胬肉的复发率无显著影响。
[Key word]
[Abstract]
AIM: To observe the efficacy of surgical excision combined with autologous limbus conjunctival flap transplantation in the treatment of pterygium accompanied with conjunctival cyst.
METHODS: Totally 126 patients 188 eyes with pterygium were hospitalized in Department of Ophthalmology of Tongji Hospital of Huazhong University of Science and Technology during August 2013 and August 2015. The patients were divided into two groups: observation group(11 eyes of 11 patients)with pterygium accompanied with conjunctival cyst and control group(177 eyes of 115 patients)with primary pterygium. All patients underwent slit lamp microscope examination, anterior segment photography, and anterior segment optical coherence tomography(OCT). The size of pterygium was calculated by multiplying neck width and length of the covered corneal. All patients underwent excision combined with autologous conjunctival flap transplantation, and the resections were performed pathological section with hematoxylin and eosin staining. All patients were followed up postoperatively for 4-28mo.
RESULTS: All cases in the observation group were confirmed by postoperative pathological examination. All cyst walls were complete, and containing single layer of epithelial cells. The mean size of pterygium of the observation group was 6.9±1.7mm2, and 6.3±1.8mm2 for the control group. There was no significant difference between the two groups(P>0.05). The mean postoperative healing time of observation group was 2.1±0.9d, and 1.9±0.8d for the control group. There was no significant difference between the two groups(P>0.05). Recurrence was seen in two eyes within the follow-up period in the control group, and no recurrence in the observation group.
CONCLUSION: Surgical excision combined with autologous limbus conjunctival flap transplantation is a safe and effective treatment for pterygium accompanied with conjunctival cyst.
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[基金项目]
国家自然科学基金(No.81200661,81471606); 湖北省自然科学基金(No.2014CFB973,2014CFB442)