方法：选取我院2013-10/2015-10住院部收治的翼状胬肉患者82例122眼，根据随机数表法将所有患者分为观察组39例61眼和对照组43例61眼，对照组采取单纯翼状胬肉切除术，观察组采取翼状胬肉切除联合羊膜移植术。对比术前、术后1、3mo两组患者泪膜破裂时间(break-up time， BUT)和Schirmer I试验(SⅠt)，比较术后2mo 两组患者眼球表面温度及干眼症状评分。

结果：术前对照组和观察组的BUT和SⅠt差异无统计学意义(P>0.05)； 术后1mo，观察组BUT为5.79±1.53s，明显高于对照组(4.28±0.98s)，差异有统计学意义(t=2.478，P=0.012)，观察组SⅠt为4.39±1.69mm/5min，高于对照组(3.51±0.89mm/5min)，差异无统计学意义(t=1.529，P=0.079)； 术后3mo，观察组的BUT为7.49±1.79s，明显高于对照组(6.71±1.89s)， 差异有统计学意义(t=2.271，P=0.026)，观察组的SⅠt为9.58±1.30mm/5min，高于对照组(8.91±1.49mm/5min)， 差异无统计学意义(t=1.857，P=0.068)； 术后2mo，观察组眼球表面温度为34.29℃±0.67℃，对照组为34.18℃±1.58℃， 差异无统计学意义(t=1.033，P=0.278)； 术后2mo，观察组干眼症状评分为3.87±0.14分，明显低于对照组(5.34±0.78分)， 差异有统计学意义(t=14.463，P<0.01)。

结论：翼状胬肉切除联合羊膜移植术能有效改善干眼症，有利于泪膜功能的稳定。

METHODS: Totally 82 cases(122 eyes)with pterygium treated in our hospital from October 2013 to October 2015 were selected and divided into observation group 39 cases(61 eyes)and control group 43 cases(61 eyes)by the random number table method. The control group was treated with simple pterygium excision, the observation group was treated with pterygium excision combined with amniotic membrane transplantation. The comparison of tear break-up time(BUT)and Schirmer I test(SⅠt)at preoperatively, 1, 3mo postoperatively between the two groups, ocular surface temperature and dry eye symptoms at 2mo were taken.

RESULTS: There was no significant difference in BUT and SⅠt between the control group and the observation group before operation(P>0.05). At 1mo after operation, the BUT of the observation group was 5.79±1.53s, which was significantly higher than that of the control group(4.28±0.98s)(t=2.478, P=0.012); the SⅠt of the observation group was 4.39±1.69mm/5min, higher than that of the control group(3.51±0.89mm/5min)(t=1.529, P=0.079). At 3mo after operation, the BUT of the observation group was 7.49±1.79s, significantly higher than that of the control group(6.71±1.89s)(t=2.271, P=0.026); the SⅠt of observation group was 9.58±1.30mm/5min, higher than the control group(8.91±1.49mm/5min)(t=1.857, P=0.068). At 2mo after operation, the eye of the observation group showed that the temperature was 34.29℃±0.67℃, higher than that of the control group(34.18℃±1.58℃)(t=1.033, P=0.278); the dry eye symptom score in the observation group(3.87±0.14)was significantly lower than that in the control group(5.34±0.78)(t=14.463, P<0.01).

CONCLUSION: Pterygium excision combined with amniotic membrane transplantation can effectively improve the dry eye, which is conducive to the stability of tear film function.