方法：前瞻性研究阿尔茨海默病患者24例48眼，年龄、性别匹配的正常人30例60眼，所有入选者C/D<0.6，C/D差<0.2。入选者双眼进行眼压检测和傅里叶阈光学相关断层扫描检测视网膜神经纤维层厚度及黄斑区节细胞复合体的厚度。

结果：与正常对照相比，AD患者简易精神状态检查(mini-mental state examination，MMSE)量表评分明显高于正常对照(P<0.01)； AD患者眼压为12.7±2.8mmHg，低于正常对照组(14.36±3.3mmHg)，差异具有统计学意义(P<0.05)； AD患者与正常对照在视网膜神经纤维层厚度及黄斑区节细胞复合体厚度上未发现统计学差异(P>0.05)。

结论：AD患者眼压较正常偏低，可能对AD患者青光眼性视神经损伤是一种保护机制。

METHODS: Prospective observational study. Totally 24 AD subjects and 30 age- and sex-matched controls were enrolled. All of the subjects had a cup-to-disc ratio(CDR)less than 0.6 and asymmetry of less than 0.2 between right and left eyes. Retinal nerve fiber layer(RNFL)thickness and macular ganglion cell complex(mGCC)thickness were obtained using Fourier domain optical coherence tomography. The intraocular pressure(IOP)was also measured.

RESULTS: Mini-mental state examination(MMSE)scores were significantly higher in the AD group compared with controls(P<0.01). AD patients also showed lower IOP(12.7±2.8mmHg vs 14.36±3.3mmHg; P<0.05). However, these was no significant difference in RNFL thickness and mGCC thickness between the two groups(P>0.05).

CONCLUSION: Patients with AD have lower IOP, which suggesting a protection mechanism of optic nerve damage in AD patients.