[关键词]
[摘要]
骨形态发生蛋白(bone morphogenetic proteins，BMPs)属转化生长因子β(transforming growth factor-β，TGF-β)超家族成员，是1965年由Urist等首先从脱钙骨基质提取物中分离得到的一种具有独特异位骨和软骨诱导活性的酸性蛋白质。BMP4作为BMPs家族成员之一，不仅促进软骨细胞的分化和发育，还对眼部细胞起着重要的调控作用，其在角膜上皮细胞、角膜细胞和角膜内皮细胞中表达，可以介导视网膜血管内皮细胞的凋亡并抑制血管的生成，且对角膜上皮细胞的发育起着重要作用等。本文总结近年来BMP4在眼部组织的研究进展，对BMP4在眼不同发育阶段的功能情况做一简要综述。
[Key word]
[Abstract]
Bone morphogenetic proteins(BMPs)belongs to the transforming growth factor beta(TGF-β)superfamily, which was isolated from the decalcified bone matrix by Urist in 1965.As one of the members of BMPs family, BMP4 not only promotes the differentiation and development of chondrocytes, but also plays an important role in the regulation of eye cells. BMP4 can mediate apoptosis of retinal vascular endothelial cells and inhibit angiogenesis, and is expressed in adult corneal epithelium, corneal cells and corneal endothelial cells. Also, participated in the layered corneal epithelium cells proliferation. In this paper, the recent advances in the study of BMP4 in ocular tissues are summarized, and the function of BMP4 in different developmental stages of eye is briefly reviewed.
[中图分类号]
[基金项目]
吉林大学白求恩支持计划(No.470110000520); 吉林大学优秀青年教师培养计划(No.419080500586)
