[关键词]
[摘要]
JNK，即c-Jun氨基末端激酶，是丝裂原活化蛋白激酶(mitogen activated protein kinase， MAPK)家族中一员。近些年有关它的研究一直相当活跃，它被发现与生物细胞增殖、凋亡、分化有着紧密联系，同时，许多疾病的发生也与它的活化密切相关。本文将通过详细阐述JNK信号通路与眼部结构所受各胞外刺激的关系，介绍最新研究进展，从而为治疗眼部疾病找到新的参考依据。
[Key word]
[Abstract]
JNK,which is called the c-Jun N-terminal kinase, is a member of mitogen activated protein kinases, located in cytoplasm. The studies on JNK have been quite active recently. It not only has close connections to cell generation, differentiation and apoptosis, but also plays a crucial role in numerous diseases. This paper expounds the relationship between JNK signaling pathway and extracellular stimuli in the eye structure, and introduces the latest achievement, so as to find the new references for therapy among eye diseases.
[中图分类号]
[基金项目]
吉林大学白求恩支持计划(No.470110000520); 吉林大学优秀青年教师培养计划(No.419080500586)
