方法：选用标准家兔28只，右眼为术眼，随机分成3组， A组12只，B组12只，C组4只。A组：玻璃体切割联合玻璃体腔填充硅油组； B组：玻璃体切割联合玻璃体腔填充重硅油组； C组：玻璃体切割联合玻璃体腔填充平衡盐溶液组。对实验动物术眼术前与术后不同时间段测得的视网膜后极部厚度、眼压及视网膜电图b波振幅值进行统计分析。

结果：实验A、B组及对照C组术前及术后不同时间点测得的术眼眼压经过两两比较，无统计学差异(P>0.05)； A、B、C组经两两比较，在术后第24wk时经OCT测得的术眼视网膜后极部厚度值均有统计学差异(P<0.05)； 在术后第24wk时术眼ERG的b波振幅均值有显著统计学差异(P<0.01)。

结论：硅油或者重硅油在作为玻璃体腔内填充物后，对兔眼术后眼压中长期内的影响无明显差别； 重硅油在填充后对兔眼视网膜视觉信息传导功能的负面影响，导致视网膜变薄的程度要明显大于普通硅油。

METHODS: Totally 28 standard rabbits were selected with right eyes operated for vitrectomy, and then, they were randomized into three groups: Group A 12 rabbis, Group B 12 rabbits, Group C 4 rabbits. Group A: vitreous body was cut-down and filled with silicon oil; Group B: vitreous body was cut-down and filled with heavy silicon oil; Group C: vitreous body was cut-down and filled with BSS. Taken into account were the experimental animals' different periods thickness of the retinal, intraocular pressure and ERG b-wave amplitude for statistical analysis.

RESULTS: Comparison between any two means of Group A, B or C surgery eyes' preoperative and postoperative at different time points: measured IOP showed no significant difference(P> 0.05); the retinal thickness mean value measured by OCT had statistically significant(P<0.05)at the postoperative 24wk; there was a conspicuous statistically significant(P<0.01)of ERG'sb-wave amplitude at the postoperative 24wk.

CONCLUSION: As the stuffing of vitreous cavity, the silicone oil or heavy silicone oil has no obvious difference to the influence of intraocular pressure for medium to longer term. But heavy silicone oil has more serious negative impact of retinal visual information transmission function, more significantly reduce of retinal thickness than ordinary silicone oil in the longer term.