方法：回顾性分析2014-06/2016-01本院300例318眼翼状胬肉患者的临床资料，根据手术方式分为两组，其中对照组(70例77眼)采用单纯手术切除，观察组(230例241眼)采用手术切除联合角膜缘干细胞移植进行治疗。观察术后复发率、角膜上皮切口愈合时间、角膜上皮愈合分级、疼痛评分及泪膜破裂时间。

结果：两组患者角膜上皮切口愈合时间分别为5.2±1.9、6.4±1.7d，观察组短于对照组，差异有统计学意义(P<0.05)。观察组全部痊愈，无复发； 对照组痊愈70眼，复发7眼，复发率9.1%； 两组复发率比较，差异有统计学意义(P<0.05)。术后1wk，两组患者角膜上皮愈合分级和疼痛评分比较，差异无统计学意义(P>0.05)； 术后2wk，观察组角膜上皮愈合分级优于对照组，疼痛评分低于对照组，差异均有统计学意义(P<0.05)。术前两组患者泪膜破裂时间比较，差异无统计学意义(P>0.05)； 术后1、2wk，观察组泪膜破裂时间长于对照组(P<0.05)。

结论：角膜缘干细胞移植能够有效地预防翼状胬肉术后复发，且其术后组织修复效果优于单纯手术者。

METHODS: Totally 300 patients(318 eyes)with pterygium were divided into 2 groups according to treatment methods. Patients of the control group(70 patients with 77 eyes)were given simple surgical resection, while patients of the observation group(230 patients with 241 eyes)were given corneal limbus stem cells transplantation after surgical resection. The postoperative recurrent rate, corneal epithelium incision healing time, corneal epithelium healing degree, pain score and tear film break-up time were observed.

RESULTS: The corneal epithelium incision healing time of the observation group and control group were respectively 5.2±1.9d and 6.4±1.7d, and the difference had statistical significance(P<0.05). There was no patient recurred in the observation group, while there were 7 eyes(9.1%)recurred in the control group, and the difference between groups had statistical significance(P<0.05). At 1wk after treatment, there was no significant difference in corneal epithelium healing degree and pain score between groups(P>0.05). At 2wk after treatment, the corneal epithelium healing degree of the observation group was better, and the pain score of the observation group was lower than those of the control group, the differences between groups had statistical significance(P<0.05). Before treatment, there was no significant difference in tear film break-up time between groups(P>0.05). At 1 and 2wk after treatment, the tear film break-up time of the observation group was longer than that of the control group(P<0.05).

CONCLUSION: Corneal limbus stem cell transplantation can prevent postoperative recurrence of pterygium effectively, and its postoperative tissue repair effect is superior to simple surgery.