方法：双眼屈光不正所致视疲劳青少年患者60例据数字表法随机分为2组，对照组(n=30例)滴加同批次安慰剂治疗； 观察组(n=30例)滴加七叶洋地黄双苷滴眼液治疗，两组疗程均为6mo。比较两组临床疗效，治疗前后舒适度评分、屈光检查结果及不良反应。

结果：观察组治疗总有效率(97%)明显高于对照组(33%)，差异有统计学意义(P<0.05)； 两组治疗前舒适度评分比较无显著统计学差异(P>0.05)，治疗后对照组舒适度评分无明显改善(P>0.05)，观察组治疗后舒适度评分较治疗前和对照组治疗后均明显升高(P<0.05)； 两组治疗前左眼及右眼屈光检查结果比较无显著统计学差异(P>0.05)，治疗后对照组左眼及右眼屈光检查结果无明显改善(P>0.05)，观察组治疗后左眼及右眼屈光检查结果较治疗前和对照组治疗后均明显改善(P<0.05)； 观察组心律失常、胃肠道反应、神经精神官能症等不良反应发生率(17%)与对照组(10%)比较无显著统计学差异(P>0.05)。

结论：七叶洋地黄双苷滴眼液治疗青少年屈光不正所致视疲劳疗效显著，不良反应少。

METHODS: A total of 60 cases of teenagers' patients with apparent fatigue caused by ametropia were randomly divided into 2 groups according to visual fatigue, the control group(n=30 cases)was treated with the same batch of placebo, and the observation group(n=30 cases)was treated with esculin and digitalis glycosides eye drops, two groups were treated for 6mo. The clinical efficacy of the two groups, the comfort score and refraction test results of the two groups before and after treatment, and adverse reactions were compared.

RESULTS: The total efficiency of the observation group(97%)was significantly higher than that of the control group(33%)(P<0.05). The comfort score of two groups before treatment showed no significant difference(P>0.05), the comfort score of the control group had no obvious improvement after treatment(P>0.05), and the comfort score of the observation group after treatment significantly increased more than that of before treatment and control group after treatment(P<0.05). The refractive examination results of left and right eye in two groups before treatment showed no significant difference(P>0.05), the refractive examination results of left and right eye in the control group after treatment showed no obvious improvement(P>0.05), and the refractive examination results of left and right eye in the observation group after treatment significantly improved than those of before treatment and control group after treatment(P<0.05). The adverse reaction of arrhythmia, gastrointestinal reaction, nerve neurosis incidence in the observation group(17%)had no significant difference with the control group(10%)(P>0.05).

CONCLUSION: The treatment of esculin and digitalis glycosides eye drops for teenagers' apparent fatigue caused by ametropia has a significant effect, less adverse reactions.