方法：选取我院2014-01/2015-12门诊部确诊为糖尿病眼病患者56例，根据实际病情分为早期PDR组和重度NPDR组，两组均给予PRP。

结果：重度NPDR组术前上方为114.26±18.26μm，明显高于术后的105.55±11.73μm，差异有统计学意义(t=2.085，P=0.042)； 术前下方为118.85±20.16μm，明显高于术后的107.37±16.38μm，差异有统计学意义(t=2.296，P=0.026)； 术前鼻侧、颞侧略高于术后，但差异均无统计学意义(P>0.05)； 术后平均厚度为90.16±14.81μm，明显低于术前(99.85±17.28μm)，差异有统计学意义(t=2.212，P=0.031)； 早期PDR组术后上方、下方均明显低于术前，差异有统计学意义(P<0.01)； 术后鼻侧、颞侧均略低于术前，两组差异均无统计学意义(P>0.05)； 术后平均厚度为87.58±16.08μm，明显低于术前(97.17±13.46μm)，差异有统计学意义(t=2.463，P=0.017)； 重度NPDR组术后6mo的上方、下方、颞侧与平均厚度与早期PDR组差异均无统计学意义(P>0.05)； 重度NPDR组术后6mo鼻侧为66.29±9.36μm，明显高于早期PDR组(59.88±11.71μm)，差异有统计学意义(t=2.252，P=0.028)。

结论：PRP对视网膜上下象限厚度及平均厚度影响较为显著，导致视网膜RNFL变薄，临床应注意PRP对视网膜神经细胞的损伤。

METHODS: Fifty-six cases were diagnosed as diabetic eye disease in our hospital from Jan.2014 to Dec.2015. According to the actual condition, the patients were divided into early PDR group and severe NPDR group. The two groups were given the whole retinal photocoagulation.

RESULTS: The upper part of the severe NPDR group was(114.26±18.26)μm, which significantly higher than that of postoperative(105.55±11.73)μm(t=2.085, P=0.042). The lower part was(118.85±20.16)μm, which significantly higher than that of(107.37±16.38)μm(t=2.296, P=0.026). Preoperative nasal side, the temporal side was slightly higher than the postoperative, but the difference was not statistically significant(P>0.05). The average thickness was(90.16±14.81)μm, which significantly lower than that of(99.85±17.28)μm(t=2.212, P=0.031). The upper part of the PDR group was significantly lower than that before operation, and the difference was statistically significant(P<0.01). At the nasal side, the temporal side was slightly lower than the preoperative, the difference between two groups was not statistically significant(P>0.05). The average thickness was(87.58±16.08)μm, which significantly lower than that before operation(97.17±13.46)μm(t=2.463, P=0.017). There was no significant difference in the average thickness of the temporal and the early PDR group(P>0.05)in the upper and lower sides of the severe group NPDR after 6mo. The nasal side of severe NPDR group was(66.29±9.36)μm, which significantly higher than that in early PDR group(59.88±11.71)μm, and the difference was statistically significant(t=2.252, P=0.028).

CONCLUSION: Laser photocoagulation has a significant influence on the thickness and the average thickness of the upper and lower quadrant of the retina, which leads to the thinning of retinal RNFL, and the clinical attention should be paid to the injury of retinal nerve cells.