[关键词]
[摘要]
年龄相关性黄斑变性(age-related macular degeneration，AMD)是世界范围内中老年人视力丧失的主要疾病之一，是多病因多因素多机制介导的慢性退行性眼科疾病。AMD确切发病机制仍不明确，众多研究发现年龄、遗传、营养失衡、表观遗传学、氧化应激、补体激活和炎症反应等多种因素参与其发病。 近年来研究发现机体维生素D水平和DNA甲基化与AMD发病有一定关系。 以下将维生素D缺乏和DNA甲基化在AMD发病机制的作用进行简要综述。
[Key word]
[Abstract]
Age-related macular degeneration(AMD)is one of the main diseases in the world leading to vision loss in the elderly, and is a multi-factorial and multi-mechanism mediated chronic degenerative eye disease. The exact pathogenesis of AMD is still not clear, and many studies found that age, genetic factors, nutritional imbalance, epigenetics, oxidative stress, a variety of complement factors activation and inflammatory reaction were involved in the pathogenesis. Recent studies have found that vitamin D levels and DNA methylation were closely related to AMD. Thus, a simple generalization of vitamin D deficiency and DNA methylation in the pathogenesis of AMD were made.
[中图分类号]
[基金项目]
黑龙江省博士后资助经费(No.LBH-Z15154)
