新鲜羊膜在儿童共同性斜视缝线调整显微手术中的应用

Application of fresh amniotic membrane in microscopic adjustable suture surgery of intercommunity strabismus in childhood

摘要:

目的：探讨新鲜羊膜在儿童共同性斜视缝线调整显微手术中的应用疗效，为临床治疗提供指导。

方法：应用临床随机对照研究方法，依据眼科门诊就诊号将 2010-01/2015-10在我科住院并行显微斜视矫正术的60例112眼儿童共同性斜视患者平均分为两组，A组30例58眼行直肌后徙缝线调整联合羊膜移植术， B组30例54眼行单纯直肌后徙缝线调整术，斜视矫正术后随访均≥6mo。

结果：斜视患者27例48眼术后眼位需调整，眼位需调整率为42.9%。术后1mo，眼位可调整18例29眼，其中A组16例26眼，眼位可调整率为44.8%，眼位可调整量平均为2.56±0.64mm； B组2例3眼，眼位可调整率为5.6%，眼位可调整量平均为0.52±0.28mm，两组比较眼位可调整率及可调整量差异均有统计学意义(χ²=22.477，P<0.01； t=16.502，P<0.01)。除3例患儿术后不配合眼位调整外，其余均在术后1mo内行不同程度的眼位调整，眼位调整后，A组27例53眼眼位正位，正位率为91.4%， B组16例28眼眼位正位，正位率为51.9%，两组比较斜视术后正位率差异有统计学意义(χ²=21.827，P<0.01)。

结论：在儿童共同性斜视缝线调整显微手术过程中应用新鲜羊膜效果确切，可明显延长眼位调整时间及增加眼位调整量，提高了儿童斜视手术的可控性和成功率。

Abstract:

AIM: To discuss the clinical efficacy of fresh amniotic membrane(AM)during the microscopic adjustable suture surgery in children's intercommunity strabismus, in order to guide clinical treatment.

METHODS: With the clinical randomized control study(RCT), 60(112 eyes)cases of patients in childhood who received microscopic strabismus surgery in our hospital were divided them into two different groups from Jan.2010 to Oct.2015. According to the application of AM on the basis of ophthalmology outpatient number, 30 cases(58 eyes)in group A were treated with rectus muscle recession surgery combined adjustable suture combined with AM. The other 30 cases(54 eyes)in group B were treated with rectus muscle recession surgery combined adjustable suture only. All patients in two groups were followed-up over 6mo after the strabismus surgery.

RESULTS:Twenty-seven cases(48 eyes)of all the strabismus patients must be adjusted after strabismus surgery, and the eye position adjustment rate was 42.9%. At 1mo after surgery, eye position of 18 cases(29 eyes)can be adjusted in all patients, and 44.8%(16 cases, 26 eyes)in group A with the average of adjustment lengths was 2.56±0.64mm, and 5.6%(2 cases, 3 eyes)in group B, with the average of adjustment lengths was 0.52±0.28mm, the differences of the adjustment rate and the average of adjustment amount were both high statistically significant(χ²=22.477, P<0.01; t=16.502, P<0.01)between the two groups. Except of 3 cases who couldn't cooperate with eye position adjustment, they all received eye position adjustment in different degrees in one month after strabismus surgery,and after eye position adjustment, 27 cases(53 eyes)in group A got normal eye position, and the correction rate of eye position was 91.4%, and 16 cases(28 eyes)in group B got normal eye position after eye position adjustment, the correction rate was 51.9%, the differences of the correction rate were statistically significant(χ²=21.827, P<0.01)between the two groups.

CONCLUSION: The application of fresh AM in the microscopic adjustable suture strabismus surgery is exactly effective in treatment of children's intercommunity strabismus. It can significantly extend the adjustment time and increase the adjustment amount, and it also can statistically improve the controllability and achievement ratio for children's strabismus surgery.