方法：选取2015-05/12于我院行激光角膜屈光手术的高度近视患者(-6.00D≤等效球镜度数≤-10.00D)67例132眼，根据患者接受手术方式的不同分成飞秒激光制瓣联合准分子激光原位角膜磨镶术(简称FS-LASIK组)66眼和行小切口基质透镜取出术(简称SMILE组)66眼，术中SMILE组角膜帽厚度和FS-LASIK组术中角膜瓣厚度都设置为110μm。分别于术前、术后3、6mo利用Pentacam测量患者角膜后表面高度，观察对比其术前术后的角膜后表面高度的变化量。

结果：术后6mo，FS-LASIK组角膜后表面高度为6.47±1.65mm，显著高于术前5.20±1.32mm。SMILE组角膜后表面高度为6.40±1.33mm，显著高于术前5.18±1.25mm，差异均具有统计学意义(P<0.05)； 术后6mo， FS-LASIK组角膜表面高度前凸量(1.29±1.28mm)与SMILE组(1.22±0.89mm)相当，差异无统计学意义(P>0.05)。

结论：FS-LASIK和SMILE矫正高度近视术后均出现一定程度的角膜后表面前突，后表面高度值增加； FS-LASIK相较于SMILE，术后早期角膜后表面变化量略大，但无明显的临床差别，SMILE术后角膜后表面形态稳定性相对略好。

METHODS: Sixty-seven cases of high myopic patients(132 eyes)operated with laser corneal refractive in our hospital from May to Dec. in 2015(-6.00D≤spherical equivalent degree≤-10.00D)were selected and divided into FS-LASIK group and SMILE group. The thickness of corneal flaps at FS-LASIK and the thickness of map at SMILE were designed to be 110μm. Corneal posterior surface heights were examined by Pentacam at preoperation, postoperative 3 and 6mo after FS-LASIK and SMILE operation. Surface height changes after preoperative, postoperative 3 and 6mo were compared by measuring Pentacam corneal analysis system.

RESULTS: Six months after operation, the FS-LASIK posterior corneal surface height was 6.47±1.65mm, significantly higher than 5.20±1.32mm before operation. SMILE posterior corneal surface height was 6.40±1.33mm, significantly higher than 5.18±1.25mm before operation, the differences were statistically significant(P<0.05). Six month after surgery, two methods of corneal surface height variation obtained was 1.29±1.28mm and 1.22±0.89mm, there was no significant difference(P>0.05).

CONCLUSION: After FS-LASIK and SMILE, the corneal posterior surface is protrusive. FS-LASIK is slightly obvious than SMILE in early period. The stability of the posterior surface is better after SMILE.