方法：收集秦皇岛市海港医院眼科2009-01/2015-12下泪小管断裂行手术治疗的患者67例67眼的临床资料进行研究。采用数字表法随机将患者分为A组和B组。A组33例33眼行常规泪小管断裂吻合术，B组34例34眼行鼻内窥镜引导逆行注气法联合5-氟尿嘧啶治疗泪小管断裂。分别采用独立样本t检验和Mann-Whitney秩和检验的方法对两组的找到泪小管断端的时间和手术疗效进行比较。

结果：A组找到泪小管断端的时间为44.42±10.66min，B组找到泪小管断端的时间为30.06±6.21min，两组比较，差异有统计学意义(t=6.72，P<0.05)。术后6mo冲洗泪道判断手术疗效，B组疗效优于A组，差异有统计学意义(Z=2.47，P<0.05)。

结论：鼻内窥镜引导逆行注气法联合5-氟尿嘧啶治疗泪小管断裂和常规泪小管断裂吻合术相比，手术时间短，术后疗效佳。

METHODS: A total of 67 patients(67 eyes)with lower lacrimal canalicular rupture who received surgical treatment by Department of Ophthalmology in Qinhuangdao Haigang Hospital were consecutively recruited between Jan. 2009 and Dec. 2015. They were randomly divided into Group A or Group B. Group A(33 patients, 33 eyes)were treated by conventional surgery, and Group B(34 patients, 34 eyes)were treated by retrograde gas injection under nasal endoscope combined 5-Fluorouracil. Time for finding out the cute end of the lower lacrimal canaliculus and postoperative effect were recorded. Comparisons between the two groups were done with Independent sample t-test and Mann-Whitney Rank sum test.

RESULTS: Time for finding out the cute end of the lower lacrimal canaliculus of Group A was(44.42±10.66)min, and the time of Group B was(30.06±6.21)min. There was significant difference between the two groups(t=6.72, P<0.05). Lacrimal ducts flush was done at the 6mo after the survey, Group B had better effect than Group A, the difference between the two groups were significant(Z=2.47,P<0.05).

CONCLUSION: Compared with conventional surgery, retrograde gas injection under nasal endoscope combined 5-Fluorouracil for lacrimal canalicular rupture can make the operation time shorter and has better effect.