[关键词]
[摘要]
目的：观察翼状胬肉切除联合自体球结膜瓣移植术后，局部应用1g/L环孢霉素A对胬肉复发的抑制效果。
方法：对原发性翼状胬肉患者58例58眼进行前瞻性研究。所有入选眼均采用翼状胬肉切除联合自体球结膜瓣移植术，根据术后是否应用1g/L环孢霉素A滴眼液分为试验组和对照组。术后追踪随访1a，观察患者的胬肉复发率。
结果：术后试验组基础泪液分泌试验(Schirmer Ⅰ test，SⅠt)结果明显优于对照组(9.93±1.59 vs 8.47±1.53mm/5min)； SⅠt结果也显示1g/L环孢霉素A使患眼术后的泪液分泌量较术前有所增加。术后1a试验组与对照组的胬肉复发率分别为10%和 39%。对照组并发症的出现率要高于试验组，差异具有统计学意义(P=0.029)。
结论：翼状胬肉切除术后局部应用1g/L环孢霉素A滴眼液能够安全有效地降低胬肉的复发率。
[Key word]
[Abstract]
AIM: To investigate the efficacy of 1g/L topical cyclosporine A(tCsA)in preventing the recurrence of pterygium after pterygium excision and conjunctival flap rotation technique.
METHODS: Fifty-eight patients(58 eyes)with primary pterygium were included in this prospective study. All eyes were operated with pterygium excision and conjunctival flap rotation technique, and divided into treatment and control group according to whether be treated with 1g/L tCsA eye drops after operation. The operated patients were followed up for 1y to assess the recurrence of pterygium.
RESULTS: After surgery, the difference between the tCsA treatment and control group were statistically significant in the Schirmer I test results(9.93±1.59mm/5min vs 8.47±1.53mm/5min, P<0.001). The Schirmer Ⅰ test results increased after tCsA treatment for patients assigned to the treatment group. The pterygium recurred in 3 of 28 eyes(10%)in the treatment group and 11 of 30 eyes(39%)in the control group(P=0.029).
CONCLUSION: tCsA eye drops are safe and effective for medical treatment to reduce rates of recurrence after pterygium surgery.
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