方法：选取2012-01/2015-12本院眼科中心确诊的98例128眼视神经炎患者进行研究，检测患者的血清AQP4-Ab、抗核抗体(ANAs)的阳性率，根据AQP4-Ab表达进行分组，对比两组间最佳矫正视力、盘周视网膜神经纤维层厚度(pRNFL)、黄斑容积、黄斑部RNFL(mRNFL)、黄斑部内核层容积(mINL)测定值。

结果：确诊的视神经炎患者98例128眼，经过检查发现AQP4-Ab阳性患者22例(22%)，阴性患者76例(78%)； ANAs阳性患者21例(21%)，阴性患者77例(79%)； 视神经炎患者的血清AQP4-Ab阳性率与ANAs阳性率具有显著的相关关系(r=0.707，P<0.01)； 经过检查发现AQP4-Ab阳性患者和阴性患者的最佳矫正视力差异无统计学意义(P>0.05)； 经过检查发现AQP4-Ab阳性患者的pRNFL、黄斑容积测定值均显著地小于阴性患者，差异均具有统计学意义(P<0.05)； AQP4-Ab阳性患者和阴性患者的mRNFL、mINL测定值差异均无统计学意义(P>0.05)。

结论：AQP4-Ab在视神经炎患者中的阳性表达与ANAs存在显著的相关性，AQP4-Ab阳性视神经炎患者的pRNFL变薄、黄斑容积下降明显。

METHODS: A total of 98 cases(128 eyes)of patients with optic neuritis were studied to detect the patient's serum AQP4-Ab positive rate of antinuclear antibodies(ANAs)from Jan. 2012 to Dec. 2015 in ophthalmology center of our hospital. According to the expression of AQP4-Ab group, the best corrected visual acuity between the two groups, peripapillary nerve fiber layer thickness(pRNFL), the volume of the macula, macular RNFL(mRNFL), macular core layer volume(mINL)measurement were compared.

RESULTS: Ninety-eight patients(128 eyes)with optic neuritis cases diagnosed through examination revealed AQP4-Ab positive in 22 patients(22%), negative in 76 patients(78%), ANAs positive in 21 patients(21%), negative 77 patients(79%). Optic neuritis patients with serum AQP4-Ab positive rate and ANAs positive significant correlation(r=0.707, P<0.05). After examination revealed AQP4-Ab patients and negative-positive patients with best corrected visual acuity difference was not statistically significance(P>0.05). After inspection found pRNFL, macular volume measured value AQP4-Ab positive patients were significantly less than the negative patients, the differences were statistically significant(P<0.05). AQP4-Ab positive patients and negative patients the mRNFL, mINL measured values were not significantly different(P>0.05).

CONCLUSION:AQP4-Ab and ANAs expression in optic neuritis patients is a significant correlation. AQP4-Ab positive patients with optic neuritis pRNFL thinning of macular volume are decreased compared with negative patients.